SLC47A2 - solute carrier family 47 member 2 Gene

Homo sapiens

Also known as MATE2; MATE2K; MATE2-B; MATE2-K

Gene ID: 146802 | Gene type: protein coding

About SLC47A2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,678,317-19,718,979 (from NCBI)

This gene has 10 transcripts (splice variants), 282 orthologues and 1 paralogue. Restricted expression toward kidney (RPKM 17.1).

Summary

This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the Bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each Other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

SLC47A2 Products(3)

mRNA	Protein	Name
NM_001099646.3	NP_001093116.1	multidrug and toxin extrusion protein 2 isoform 2
NM_001256663.3	NP_001243592.1	multidrug and toxin extrusion protein 2 isoform 3
NM_152908.5	NP_690872.2	multidrug and toxin extrusion protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables antiporter activity	IDA IDA: Inferred from direct assay	16807400	GOA
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	16807400	GOA
enables polyspecific organic cation:proton antiporter activity	IDA IDA: Inferred from direct assay	16807400	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in organic cation transport	IDA IDA: Inferred from direct assay	16807400	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	19158817	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC47A2 Protein Structure

MatE

0
100
200
300
400
500
602 a.a.

Protein Preferred Names

Protein Names

multidrug and toxin extrusion protein 2

kidney-specific H(+)/organic cation antiporter

Related Diseases

Diseases

Alias

Thiamine Metabolism Dysfunction Syndrome 2

Biotin-Responsive Basal Ganglia Disease	Basal Ganglia Disease, Biotin-Responsive
THMD2	Bbgd
Btbgd	Encephalopathy, Thiamine-Responsive
Thiamine Metabolism Dysfunction Syndrome 2, Biotin- Or Thiamine-Responsive Type	Thiamine-Responsive Encephalopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13264	SLC47A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC47A2	RGD	RGD:1562382
Canis familiaris	SLC47A2	VGNC	VGNC:49831
Macaca mulatta	SLC47A2	VGNC	VGNC:77778
Bos taurus	SLC47A2	VGNC	VGNC:34888

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