KIF18B - kinesin family member 18B Gene

Homo sapiens

Gene ID: 146909 | Gene type: protein coding

About KIF18B

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,924,711-44,947,773 (from NCBI)

This gene has 4 transcripts (splice variants), 118 orthologues and 41 paralogues. Broad expression in bone marrow (RPKM 3.6), lymph node (RPKM 2.4) and 14 other tissues.

Summary

Enables cytoskeletal motor activity and Kinesin binding activity. Involved in microtubule depolymerization; mitotic cell cycle; and regulation of cell division. Located in cytosol; microtubule; and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

KIF18B Products(2)

mRNA	Protein	Name
NM_001264573.2	NP_001251503.1	kinesin-like protein KIF18B isoform 2
NM_001265577.2	NP_001252506.1	kinesin-like protein KIF18B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytoskeletal motor activity	IDA IDA: Inferred from direct assay	21820309	GOA
enables kinesin binding	IPI IPI: Inferred from physical interaction	21820309	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21820309	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in microtubule depolymerization	IDA IDA: Inferred from direct assay	21820309	GOA
involved in mitotic cell cycle	IDA IDA: Inferred from direct assay	20600703	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	20600703	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in astral microtubule	IDA IDA: Inferred from direct assay	21820309	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20600703	GOA
located in microtubule plus-end	IDA IDA: Inferred from direct assay	21820309	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20600703	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF18B Protein Structure

Kinesin

0
200
400
600
800
852 a.a.

Protein Preferred Names

Protein Names

kinesin-like protein KIF18B

Related Diseases

Diseases

Alias

Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation	Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome
FLPIS	Scott Bryant Graham Syndrome
Craniodigital-Intellectual Disability Syndrome	Scott Craniodigital Syndrome
Scott-Bryant-Graham Syndrome	Syndactyly, Type I, With Microcephaly And Mental Retardation
Syndactyly Type I With Microcephaly And Intellectual Disability	Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly
Craniodigital Syndrome With Intellectual Disability	Craniodigital Syndrome-Intellectual Disability Syndrome
Craniodigital Syndrome-Intellectual Disability, Scott Type	Intellectual Disability-Craniodigital Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07268	KIF18B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KIF18B	RGD	RGD:1310360
Canis familiaris	KIF18B	VGNC	VGNC:42388
Bos taurus	KIF18B	VGNC	VGNC:30588
Mus musculus	KIF18B	MGD	MGI:2446979
Felis catus	KIF18B	VGNC	VGNC:63108
Macaca mulatta	KIF18B	VGNC	VGNC:99162

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