Gpc3 - glypican 3 Gene

Mus musculus

Also known as OCI-5

Gene ID: 14734 | Gene type: protein coding

About Gpc3

Summary

Predicted to enable peptidyl-dipeptidase inhibitor activity. Involved in mesenchymal cell proliferation involved in ureteric bud development. Acts upstream of or within several processes, including animal organ development; positive regulation of transport; and regulation of signal transduction. Located in lysosome and plasma membrane. Is anchored component of plasma membrane. Is expressed in several structures, including branchial arch; future brain; lower jaw; reproductive system; and urinary system. Used to study Simpson-Golabi-Behmel syndrome type 1. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Orthologous to human GPC3 (glypican 3). [provided by Alliance of Genome Resources, Apr 2022]

Gpc3 Products(1)

mRNA	Protein	Name
NM_016697.3	NP_057906.2	glypican-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18343214	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	15537637	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	9853964	MGI
acts upstream of or within anterior/posterior axis specification	IGI IGI: Inferred from genetic interaction	10964473	MGI
acts upstream of or within body morphogenesis	IMP IMP: Inferred from mutant phenotype	18477453	MGI
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	15936336	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	15925496	MGI
acts upstream of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15537637	MGI
acts upstream of or within cell proliferation involved in kidney development	IMP IMP: Inferred from mutant phenotype	11180950	MGI
acts upstream of or within cell proliferation involved in metanephros development	IMP IMP: Inferred from mutant phenotype	10402475	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	19733558	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	10964473	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10402475	MGI
acts upstream of or within epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10402475	MGI
acts upstream of growth	IMP IMP: Inferred from mutant phenotype	15537637	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	10402475	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	10402475	MGI
involved in mesenchymal cell proliferation involved in ureteric bud development	IMP IMP: Inferred from mutant phenotype	15925496	MGI
acts upstream of or within mesonephric duct morphogenesis	IMP IMP: Inferred from mutant phenotype	11180950	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15537637	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	15925496	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10402475	MGI
acts upstream of or within negative regulation of growth	IMP IMP: Inferred from mutant phenotype	11846487	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	19590577	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	18477453	MGI
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	15936336	MGI
acts upstream of or within positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	15925496	MGI
acts upstream of or within positive regulation of D-glucose import	IDA IDA: Inferred from direct assay	18343214	MGI
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	15537637	MGI
acts upstream of or within positive regulation of endocytosis	IDA IDA: Inferred from direct assay	18477453	MGI
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	18477453	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19733558	MGI
acts upstream of or within regulation of growth	IGI IGI: Inferred from genetic interaction	19590577	MGI
acts upstream of or within regulation of growth	IMP IMP: Inferred from mutant phenotype	10402475	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
acts upstream of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19733558	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in lysosome	IDA IDA: Inferred from direct assay	18477453	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18343214	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	18477453	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glypican-3

Recombinant Gpc3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70872	Glypican-3/GPC3 Protein, Mouse (HEK293, His)	Q8CFZ4 (Q25-M557)	≥95%
HY-P73078	Glypican-3/GPC3 Protein, Mouse (sf9, His)	Q8CFZ4 (Q25-P558)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99013	Codrituzumab	Inhibitor	95.70%	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153360	MC-GGFG-AM-(10Me-11F-Camptothecin)	Inhibitor	98.06%	Unkown
HY-RS05628	GPC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990840	Anti-GPC3 Antibody (YP7)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpc3	NCBI	NCBI:2719
Macaca fascicularis	Gpc3	NCBI	NCBI:102137748

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