Gpi1 - glucose-6-phosphate isomerase 1 Gene

Mus musculus

Also known as MF; NK; Amf; Gpi; Nlk; Org; Pgi; Phi; Gpi-1; Gpi1s; Gpi-1r; Gpi-1s; Gpi-1t; Gpi1-r; Gpi1-s; Gpi1-t; NK/GPI

Gene ID: 14751 | Gene type: protein coding

About Gpi1

Summary

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic Enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Aug 2016]

Gpi1 Products(1)

mRNA	Protein	Name
NM_008155.4	NP_032181.2	glucose-6-phosphate isomerase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glucose-6-phosphate isomerase activity	IDA IDA: Inferred from direct assay	204065	MGI
enables glucose-6-phosphate isomerase activity	IMP IMP: Inferred from mutant phenotype	3796661	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17875708	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in GDP-mannose biosynthetic process from glucose	IDA IDA: Inferred from direct assay	21273394	MGI
acts upstream of or within erythrocyte homeostasis	IMP IMP: Inferred from mutant phenotype	8417789	MGI
involved in fructose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	6767907	MGI
involved in gluconeogenesis	IDA IDA: Inferred from direct assay	31891762	MGI
involved in glucose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	6767907	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	8417789	MGI
acts upstream of or within glycolytic process	IDA IDA: Inferred from direct assay	15665293	MGI
acts upstream of or within glycolytic process	IMP IMP: Inferred from mutant phenotype	8417789	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	1582174	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	8922529	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary membrane	IDA IDA: Inferred from direct assay	22179047	MGI
is active in cytosol	IDA IDA: Inferred from direct assay	6986434	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	22179047	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glucose-6-phosphate isomerase

autocrine motility factor	glucose phosphate isomerase 1 complex
glucose phosphate isomerase 1, regulatory	glucose phosphate isomerase 1, structural
glucose phosphate isomerase 1, temporal	maturation factor
neuroleukin	phosphoglucose isomerase
phos

Gpi1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Gpi	P06745	Parp14	Mus musculus	Q2EMV9	Y2H	17875708
Intra	Gpi	P06745	Parp14	Mus musculus	Q2EMV9	Confocal	17875708
Intra	Gpi	P06745	Parp14	Mus musculus	Q2EMV9	Anti Bait CoIP	17875708

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Gpi1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71738	Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His)	P06745 (A2-E558)	≥95%
HY-P72210	Glucose-6-phosphate isomerase Protein, Mouse (His-B2M)	P06745 (A2-E558)	≥95%

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