CSTF3 - cleavage stimulation factor subunit 3 Gene

Homo sapiens

Also known as CSTF-77

Gene ID: 1479 | Gene type: protein coding

About CSTF3

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:33,084,584-33,161,480 (from NCBI)

This gene has 8 transcripts (splice variants) and 233 orthologues. Ubiquitous expression in testis (RPKM 12.9), lymph node (RPKM 7.3) and 25 other tissues.

Summary

The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CSTF3 Products(3)

mRNA	Protein	Name
NM_001033505.2	NP_001028677.1	cleavage stimulation factor subunit 3 isoform 2
NM_001033506.2	NP_001028678.1	cleavage stimulation factor subunit 3 isoform 3
NM_001326.3	NP_001317.1	cleavage stimulation factor subunit 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7590244	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	IDA IDA: Inferred from direct assay	7984242	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of mRNA cleavage stimulating factor complex	IDA IDA: Inferred from direct assay	7984242	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSTF3 Protein Structure

Suf

0
200
400
600
717 a.a.

Protein Preferred Names

Protein Names

cleavage stimulation factor subunit 3

CF-1 77 kDa subunit

Related Diseases

Diseases

Alias

Oculopharyngeal Muscular Dystrophy

OPMD	Muscular Dystrophy, Oculopharyngeal
Dystrophy, Oculopharyngeal Muscular	Oculopharyngeal Dystrophy
Progressive Muscular Dystrophy, Oculopharyngeal Type	Muscular Dystrophy Oculopharyngeal
Dystrophy, Muscular, Oculopharyngeal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03276	CSTF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CSTF3	VGNC	VGNC:39684
Felis catus	CSTF3	VGNC	VGNC:61241
Macaca mulatta	CSTF3	VGNC	VGNC:71537
Mus musculus	CSTF3	MGD	MGI:1351825
Bos taurus	CSTF3	VGNC	VGNC:27783
Rattus norvegicus	CSTF3	RGD	RGD:1305901

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