2. Gene
  3. Hspa5 - heat shock protein 5 Gene

Hspa5 - heat shock protein 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Bip; Sez7; mBiP; Grp78; SEZ-7; Hsce70; baffled; D2Wsu17e; D2Wsu141e

Gene ID: 14828 | Gene type: protein coding

About Hspa5

Chromosome 2: 34,661,982-34,667,559 forward strand.GRCm39:CM000995.3

This gene has 6 transcripts (splice variants), 257 orthologues, 12 paralogues and is associated with 53 phenotypes. Ubiquitous expression in placenta adult (RPKM 321.6), genital fat pad adult (RPKM 154.1) and 28 other tissues.

Summary

Enables misfolded protein binding activity and ribosome binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; cerebellum development; and positive regulation of protein ubiquitination. Acts upstream of or within several processes, including cellular response to interleukin-4; negative regulation of transforming growth factor beta receptor signaling pathway; and toxin transport. Located in several cellular components, including cell surface; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (HSP70) member 5). [provided by Alliance of Genome Resources, Apr 2022]

Hspa5 Products(2)

mRNA Protein Name
NM_022310.3 NP_071705.3 endoplasmic reticulum chaperone BiP precursor
NM_001163434.1 NP_001156906.1 endoplasmic reticulum chaperone BiP precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables misfolded protein binding IDA
IDA: Inferred from direct assay
18923430 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11836248 MGI
enables protein folding chaperone IDA
IDA: Inferred from direct assay
23123197 MGI
enables ribosome binding IDA
IDA: Inferred from direct assay
12065409 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within ER overload response IDA
IDA: Inferred from direct assay
11854325 MGI
involved in IRE1-mediated unfolded protein response IEP
IEP: Inferred from expression pattern
24508390 MGI
acts upstream of or within cellular response to interleukin-4 IDA
IDA: Inferred from direct assay
9798653 MGI
involved in cerebellar Purkinje cell layer development IMP
IMP: Inferred from mutant phenotype
19816510 MGI
involved in cerebellum structural organization IMP
IMP: Inferred from mutant phenotype
19816510 MGI
involved in endoplasmic reticulum unfolded protein response IMP
IMP: Inferred from mutant phenotype
19816510 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
17991893 MGI
involved in positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
19816510 MGI
involved in proteolysis involved in protein catabolic process IDA
IDA: Inferred from direct assay
18923430 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
17991893 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
7679955 MGI
part of endoplasmic reticulum chaperone complex IDA
IDA: Inferred from direct assay
12475965 MGI
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
19816510 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
22589549 MGI
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
21187406 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
22837305 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hspa5 Protein Structure

HSP70

HSP70: pfam00012 (30 - 635)

  • 0
  • 200
  • 400
  • 600
  • 655 a.a.
Protein Preferred Names Protein Names

endoplasmic reticulum chaperone BiP

78 kDa glucose-regulated protein

GRP-78

HSP70 family protein 5

XAP-1 antigen

binding-immunoglobulin protein

glucose regulated protein, 78 kDa

heat shock 70 kDa protein 5

heat shock 70kD protein 5 (glucose-regulated protein, 78kD)

heat shock protein 70 family protein 5

heat shock protein family A member 5

immunoglobulin heavy chain-binding protein

Recombinant Hspa5 Proteins

Cat. No. Product Name Accession Purity
HY-P71742 HSPA5/GRP-78 Protein, Mouse (P.pastoris, His) P20029 (E20-L655) ≥95%
HY-P71742Y HSPA5/GRP-78 Protein, Mouse (P.pastoris, His, solution) P20029 (E20-L655) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125974 HM03 Inhibitor 99.34% Unkown
HY-152153 GRP78-IN-3 Inhibitor 99.98% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspa5 NCBI NCBI:3309