PHF13 - PHD finger protein 13 Gene

Homo sapiens

Also known as PHF5; SPOC1

Gene ID: 148479 | Gene type: protein coding

About PHF13

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,613,731-6,624,030 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in testis (RPKM 26.3), endometrium (RPKM 8.4) and 25 other tissues.

Summary

Enables chromatin binding activity. Involved in mitotic chromosome condensation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PHF13 Products(1)

mRNA	Protein	Name
NM_153812.3	NP_722519.2	PHD finger protein 13

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	19638409	GOA
enables chromatin-protein adaptor activity	IDA IDA: Inferred from direct assay	23034801	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	23034801	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23034801	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	19638409	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19638409	GOA
involved in mitotic chromosome condensation	IMP IMP: Inferred from mutant phenotype	19638409	GOA
involved in regulation of DNA repair	IDA IDA: Inferred from direct assay	23034801	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19638409	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF13 Protein Structure

PHD

0
100
200
300 a.a.

Protein Preferred Names

Protein Names

PHD finger protein 13

PHD zinc finger protein PHF5

Related Diseases

Diseases

Alias

Ovarian Cancer 1

Ovarian Cancer, Susceptibility To	Ovarian Cancer, Susceptibility To, 1
OVCAS1	Ovarian Cancer
Ovarian Carcinoma	Malignant Neoplasm Of Ovary
Epithelial Ovarian Cancer

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Pick Disease Of Brain

Pick Disease	Pick'S Disease
Pick Disease Of The Brain	Lobar Atrophy Of Brain
Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10417	PHF13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PHF13	VGNC	VGNC:104232
Rattus norvegicus	PHF13	RGD	RGD:1308145
Bos taurus	PHF13	VGNC	VGNC:32815
Canis familiaris	PHF13	VGNC	VGNC:59030
Felis catus	PHF13	VGNC	VGNC:107599
Mus musculus	PHF13	MGD	MGI:2446217

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