RNF187 - ring finger protein 187 Gene

Homo sapiens

Also known as RACO1; RACO-1

Gene ID: 149603 | Gene type: protein coding

About RNF187

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,487,382-228,496,188 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele and 64 orthologues. Ubiquitous expression in thyroid (RPKM 54.8), brain (RPKM 49.5) and 25 other tissues.

Summary

Enables ubiquitin-protein transferase activity. Involved in positive regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNF187 Products(1)

mRNA	Protein	Name
NM_001010858.3	NP_001010858.2	E3 ubiquitin-protein ligase RNF187

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20852630	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20852630	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20852630	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	20852630	GOA
involved in protein K48-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	20852630	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	20852630	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20852630	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20852630	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF187

RING domain AP1 coactivator 1

RNF187 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF187	Q5TA31	ZNF835	Homo sapiens	Q9Y2P0	Validated Y2H	32296183
Intra	RNF187	Q5TA31	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypermobility Of Coccyx

Coccygeal Hypermobility Syndrome

Hypermobility Of The Coccyx

Klippel-Feil Syndrome 3

Kummell'S Disease

Traumatic Spondylopathy	Kummell Disease
Kummell'S Spondylitis	Kümmelll-Verneuil Disease
Kümmell Spondylitis	Kümmell Disease
Traumatic Spondylosis

Brown-Sequard Syndrome

Brown-Squard Syndrome	Hemicord Syndrome
Hemiparaplegic Syndrome	Hemispinal Cord Syndrome
Brown-Séquard Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12071	RNF187 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNF187	RGD	RGD:1308636
Bos taurus	RNF187	VGNC	VGNC:50124
Macaca mulatta	RNF187	VGNC	VGNC:100059
Mus musculus	RNF187	MGD	MGI:1914224

Name
Email *

	Sorry, but the email address you supplied was invalid.