2. Gene
  3. Cfb - complement factor B Gene

Cfb - complement factor B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Bf; C2; Fb; H2-Bf

Gene ID: 14962 | Gene type: protein coding

About Cfb

Summary

Predicted to enable serine-type endopeptidase activity. Acts upstream of or within complement activation, alternative pathway. Predicted to be located in extracellular region. Is expressed in embryo and liver lobe. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; autoimmune disease (multiple); eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to human CFB (Complement Factor B). [provided by Alliance of Genome Resources, Apr 2022]

Cfb Products(3)

mRNA Protein Name
NM_001142706.2 NP_001136178.1 complement factor B isoform 2 precursor
NM_001402875.1 NP_001389804.1 complement factor B isoform 3 precursor
NM_008198.3 NP_032224.2 complement factor B isoform 1 precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within complement activation, alternative pathway IGI
IGI: Inferred from genetic interaction
27564415 MGI
acts upstream of or within complement activation, alternative pathway IMP
IMP: Inferred from mutant phenotype
9238044 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement factor B

C3/C5 convertase

Factor B

alternative-complement pathway C3/C5 convertase

complement component 2 (within H-2S)

histocompatibility 2, complement component factor B

properdin

Recombinant Cfb Proteins

Cat. No. Product Name Accession Purity
HY-P72137 Complement Factor B/CFB Protein, Mouse (His) P04186 (T23-L761) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148370 IONIS-FB-LRx Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148370A IONIS-FB-LRx sodium Inhibitor 93.90% Unkown
HY-RS02557 CFB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cfb NCBI NCBI:629