ADRA2A - adrenoceptor alpha 2A Gene

Homo sapiens

Also known as ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR

Gene ID: 150 | Gene type: protein coding

About ADRA2A

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:111,077,029-111,080,907 (from NCBI)

This gene has 1 transcript (splice variant), 230 orthologues and 18 paralogues.

Summary

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit Adenylate Cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in Catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]

ADRA2A Products(1)

mRNA	Protein	Name
NM_000681.4	NP_000672.3	alpha-2A adrenergic receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-2C adrenergic receptor binding	IPI IPI: Inferred from physical interaction	16605244	GOA
enables alpha2-adrenergic receptor activity	EXP EXP: Inferred from Experiment	10948191	GOA
enables alpha2-adrenergic receptor activity	IDA IDA: Inferred from direct assay	10948191	GOA
enables epinephrine binding	IDA IDA: Inferred from direct assay	2823383	GOA
enables heterotrimeric G-protein binding	IDA IDA: Inferred from direct assay	10948191	GOA
enables norepinephrine binding	IDA IDA: Inferred from direct assay	2823383	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16531006	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	16605244	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16605244	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15653687	GOA
enables thioesterase binding	IPI IPI: Inferred from physical interaction	19477270	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	17215105	GOA
involved in activation of protein kinase B activity	IDA IDA: Inferred from direct assay	17215105	GOA
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	15653687	GOA
involved in adenylate cyclase-inhibiting adrenergic receptor signaling pathway	IDA IDA: Inferred from direct assay	10948191	GOA
involved in adrenergic receptor signaling pathway	IDA IDA: Inferred from direct assay	10948191	GOA
involved in cellular response to hormone stimulus	IGI IGI: Inferred from genetic interaction	10948198	GOA
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	10952463	GOA
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	10952463	GOA
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	19965390	GOA
involved in negative regulation of lipid catabolic process	IGI IGI: Inferred from genetic interaction	10948198	GOA
involved in phospholipase C-activating adrenergic receptor signaling pathway	IDA IDA: Inferred from direct assay	10948191	GOA
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	19477270	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	10948191	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17655843	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	17655843	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	17655843	GOA
involved in positive regulation of membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	17655843	GOA
involved in positive regulation of wound healing	IMP IMP: Inferred from mutant phenotype	17655843	GOA
involved in receptor transactivation	IDA IDA: Inferred from direct assay	17215105	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19477270	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	2823383	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	10948191	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADRA2A Protein Structure

7tm_1

0
100
200
300
400
465 a.a.

Protein Preferred Names

Protein Names

alpha-2A adrenergic receptor

adrenergic, alpha-2A-, receptor

Related Diseases

Diseases

Alias

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Motion Sickness

Airsickness	Carsickness
Seasickness	Travel Sickness
Riders' Vertigo

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Oppositional Defiant Disorder

Disorder	Oppositional Defiance
Behavioural Disorder	Oppositional Defiance
Disruptive Mood Dysregulation Disorder

Constipation

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Specific Developmental Disorder

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N8728	Aposcopolamine		98.44%	Unkown
HY-145700	UCSF648		/	Unkown
HY-163694	ADRA2A antagonist 1	Antagonist	/	Unkown
HY-RS00411	ADRA2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-134125	Yohimbic acid ethyl ester	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ADRA2A	VGNC	VGNC:52983
Mus musculus	ADRA2A	MGD	MGI:87934
Rattus norvegicus	ADRA2A	RGD	RGD:2056
Macaca mulatta	ADRA2A	VGNC	VGNC:100292
Bos taurus	ADRA2A	VGNC	VGNC:106632
Others	ADRA2A	NCBI

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