TTL - tubulin tyrosine ligase Gene

Homo sapiens

Gene ID: 150465 | Gene type: protein coding

About TTL

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:112,482,156-112,541,739 (from NCBI)

This gene has 4 transcripts (splice variants) and 176 orthologues. Ubiquitous expression in brain (RPKM 13.3), lung (RPKM 7.4) and 24 other tissues.

Summary

TTL is a cytosolic Enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]

TTL Products(2)

mRNA	Protein	Name
NM_001371712.1	NP_001358641.1	tubulin--tyrosine ligase isoform 2
NM_153712.5	NP_714923.1	tubulin--tyrosine ligase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables tubulin-tyrosine ligase activity	IMP IMP: Inferred from mutant phenotype	25908662	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	25908662	GOA
involved in post-translational protein modification	IMP IMP: Inferred from mutant phenotype	25908662	GOA
involved in regulation of metaphase plate congression	IMP IMP: Inferred from mutant phenotype	25908662	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in spindle microtubule	IDA IDA: Inferred from direct assay	25908662	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTL Protein Structure

TTL

0
100
200
300
377 a.a.

Protein Preferred Names

Protein Names

tubulin--tyrosine ligase

2410003M22Rik

Related Diseases

Diseases

Alias

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15227	TTL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TTL	VGNC	VGNC:47972
Felis catus	TTL	VGNC	VGNC:66684
Rattus norvegicus	TTL	RGD	RGD:621113
Mus musculus	TTL	MGD	MGI:1916987
Bos taurus	TTL	VGNC	VGNC:36488
Others	TTL	NCBI

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