GPAT2 - glycerol-3-phosphate acyltransferase 2, mitochondrial Gene

Homo sapiens

Also known as CT123

Gene ID: 150763 | Gene type: protein coding

About GPAT2

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,021,946-96,036,265 (from NCBI)

This gene has 12 transcripts (splice variants), 191 orthologues and 2 paralogues. Broad expression in testis (RPKM 7.1), spleen (RPKM 3.6) and 22 other tissues.

Summary

Enables glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in several processes, including glycerol-3-phosphate metabolic process; glycerolipid biosynthetic process; and piRNA biosynthetic process. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPAT2 Products(9)

mRNA	Protein	Name
NM_001321525.2	NP_001308454.1	glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2
NM_001321526.2	NP_001308455.1	glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2
NM_001321527.2	NP_001308456.1	glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2
NM_001321528.2	NP_001308457.1	glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 3
NM_001321529.2	NP_001308458.1	glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 4
NM_001321530.2	NP_001308459.1	glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 5
NM_001321531.2	NP_001308460.1	glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 6
NM_001389639.1	NP_001376568.1	glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 9
NM_207328.4	NP_997211.2	glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycerol-3-phosphate O-acyltransferase activity	EXP EXP: Inferred from Experiment	18238778	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glycerol-3-phosphate acyltransferase 2, mitochondrial

1-acylglycerol-3-phosphate O-acyltransferase GPAT2

Related Diseases

Diseases

Alias

Coenzyme Q10 Deficiency, Primary, 9

COQ10D9

Primary Coenzyme Q10 Deficiency 9

Fetal Akinesia Deformation Sequence 4

FADS4	Fetal Akinesia Deformation Sequence Syndrome 4
Akinesia, Fetal, Deformation Sequence, Type 4

Complete Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized, Type 2

Congenital Generalized Lipodystrophy Type 2	CGL2
Berardinelli-Seip Congenital Lipodystrophy Type 2	Berardinelli-Seip Syndrome
Brunzell Syndrome Bscl2-Related	Total Lipodystrophy And Acromegaloid Gigantism
Berardinelli-Seip Congenital Lipodystrophy, Type 2	Seip Syndrome
Berardinelli Syndrome	Lipodystrophy, Total, And Acromegaloid Gigantism
Lipoatrophic Diabetes, Congenital	Lipodystrophy, Berardinelli-Seip Congenital, Type 2
Brunzell Syndrome, Bscl2-Related	Congenital Lipoatrophic Diabetes
Congenital Generalized Lipodystrophy 2	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence	Fads
Fetal Akinesia Sequence	FADS1
Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia	Pena-Shokeir Syndrome Type 1
Fetal Akinesia Deformation Sequence Syndrome	Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome
Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia	Pena-Shokeir Syndrome, Type I
Foetal Akinesia Deformation Sequence Syndrome	Foetal Akinesia Sequence
Fetal Akinesia Deformation Sequence Syndrome 1	Pena-Shokeir Syndrome, Type 1
Pena Shokeir Syndrome, Type 1	Akinesia, Fetal, Deformation Sequence
Akinesia, Fetal, Deformation Sequence, Type 1	Pena-Shokeir Syndrome Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05616	GPAT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GPAT2	VGNC	VGNC:62653
Rattus norvegicus	GPAT2	RGD	RGD:1304904
Canis familiaris	GPAT2	VGNC	VGNC:41362
Bos taurus	GPAT2	VGNC	VGNC:29512
Mus musculus	GPAT2	MGD	MGI:2684962
Macaca mulatta	GPAT2	VGNC	VGNC:73018

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