TCF23 - transcription factor 23 Gene

Homo sapiens

Also known as OUT; TCF-23; bHLHa24

Gene ID: 150921 | Gene type: protein coding

About TCF23

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,149,004-27,156,974 (from NCBI)

This gene has 2 transcripts (splice variants), 180 orthologues and 13 paralogues. Biased expression in endometrium (RPKM 12.5), ovary (RPKM 9.5) and 2 other tissues.

Summary

The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. [provided by RefSeq, May 2010]

TCF23 Products(1)

mRNA	Protein	Name
NM_175769.3	NP_786951.1	transcription factor 23

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within decidualization	IMP IMP: Inferred from mutant phenotype	24571987	GOA
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24571987	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCF23 Protein Structure

HLH

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

transcription factor 23

class A basic helix-loop-helix protein 24

Related Diseases

Diseases

Alias

Retinal Arteries, Tortuosity Of

Retinal Arterial Tortuosity	Retinal Hemorrhage With Vascular Tortuosity
RATOR	Tortuosity Of Retinal Arteries
Retinal Arteriolar Tortuosity	Familial Isolated Retinal Arterial Tortuosity
Tortuosity, Arteries, Retinal

Ras-Associated Autoimmune Leukoproliferative Disorder

RALD	Autoimmune Lymphoproliferative Syndrome Type 4
Alps4	Autoimmune Lymphoproliferative Syndrome, Type Iv
Ras-Associated Autoimmune Leukoproliferative Disease	Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic
Alps Type 4	Alps Type Iv
Autoimmune Lymphoproliferative Syndrome Type Iv	Autoimmune Lymphoproliferative Syndrome 4

Fanconi Anemia, Complementation Group E

Fanconi Anemia Complementation Group E	FANCE
Face	Faces Syndrome

Western Equine Encephalitis

Western Equine Encephalomyelitis	Wee
Encephalomyelitis, Western Equine	Western Equine Encephalitis Virus Infection
Wee - [Western Equine Encephalitis]	Western Equine Encephalitis Virus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14304	TCF23 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TCF23	VGNC	VGNC:35691
Felis catus	TCF23	VGNC	VGNC:81235
Macaca mulatta	TCF23	VGNC	VGNC:79156
Rattus norvegicus	TCF23	RGD	RGD:1586500
Canis familiaris	TCF23	VGNC	VGNC:47194
Mus musculus	TCF23	MGD	MGI:1934960

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