Has2 - hyaluronan synthase 2 Gene

Mus musculus

Gene ID: 15117 | Gene type: protein coding

About Has2

Summary

Enables hyaluronan synthase activity. Involved in several processes, including circulatory system development; extracellular polysaccharide biosynthetic process; and hyaluronan biosynthetic process. Acts upstream of or within bone morphogenesis and hyaluronan metabolic process. Located in cytoplasmic vesicle and plasma membrane raft. Is expressed in several structures, including alimentary system; brain; heart; sensory organ; and skin. Orthologous to human HAS2 (hyaluronan synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

Has2 Products(2)

mRNA	Protein	Name
NM_008216.3	NP_032242.3	hyaluronan synthase 2
NM_008216.3	NP_032242.3	hyaluronan synthase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hyaluronan synthase activity	IDA IDA: Inferred from direct assay	10455188	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in atrioventricular canal development	IMP IMP: Inferred from mutant phenotype	10930438	MGI
acts upstream of or within bone morphogenesis	IMP IMP: Inferred from mutant phenotype	21246657	MGI
involved in endocardial cushion to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	10930438	MGI
involved in extracellular matrix assembly	IDA IDA: Inferred from direct assay	10455188	MGI
involved in extracellular polysaccharide biosynthetic process	IDA IDA: Inferred from direct assay	10455188	MGI
involved in hyaluronan biosynthetic process	IDA IDA: Inferred from direct assay	8798545	MGI
involved in hyaluronan biosynthetic process	IMP IMP: Inferred from mutant phenotype	10930438	MGI
acts upstream of or within hyaluronan metabolic process	IMP IMP: Inferred from mutant phenotype	21246657	MGI
involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	10930438	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24057227	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	24057227	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	10455188	MGI
located in plasma membrane raft	IDA IDA: Inferred from direct assay	22383528	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hyaluronan synthase 2

HA synthase 2	hyaluronan synthase homolog
hyaluronate synthase 2	hyaluronic acid synthase 2

Recombinant Has2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72222	HAS2 Protein, Mouse (His)	P70312 (E67-L374)	≥95%

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14803	Tasimelteon	Agonist	99.68%	Yes

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116973	L 738372	Inhibitor	/	Unkown
HY-RS06007	HAS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-14803S	Tasimelteon-d5	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Has2	NCBI	NCBI:3037

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