2. Gene
  3. PPM1L - protein phosphatase, Mg2+/Mn2+ dependent 1L Gene

PPM1L - protein phosphatase, Mg2+/Mn2+ dependent 1L Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP2CE; PPM1-LIKE; PP2C-epsilon

Gene ID: 151742 | Gene type: protein coding

About PPM1L

Cytogenetic location: 3q25.33-q26.1 Genomic coordinates (GRCh38): 3:160,756,231-161,078,902 (from NCBI)

This gene has 5 transcripts (splice variants), 270 orthologues and 16 paralogues. Ubiquitous expression in brain (RPKM 9.7), thyroid (RPKM 6.9) and 24 other tissues.

Summary

The protein encoded by this gene is a magnesium or manganese-requiring Phosphatase that is involved in several signaling pathways. The encoded protein downregulates Apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to Apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

PPM1L Products(3)

mRNA Protein Name
NM_001317911.2 NP_001304840.1 protein phosphatase 1L isoform 2
NM_001317912.2 NP_001304841.1 protein phosphatase 1L isoform 3
NM_139245.4 NP_640338.2 protein phosphatase 1L isoform 1

PPM1L Protein Structure

PP2C

PP2C: Protein phosphatase 2C (94 - 344)

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  • 360 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1L

PP2C epsilon

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 3

IBD3
Inflammatory Bowel Disease 6

IBD6
Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1

IBD1

Crohn Disease-Associated Growth Failure

Crohn Disease

Regional Enteritis

Ulcerative Colitis

Crohn Disease-Associated Growth Failure, Susceptibility To

Inflammatory Bowel Disease 1, Crohn Disease

Bowel Disease, Inflammatory, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10969 PPM1L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPM1L RGD RGD:1305220
Macaca mulatta PPM1L VGNC VGNC:76265
Canis familiaris PPM1L VGNC VGNC:44871
Felis catus PPM1L VGNC VGNC:64314
Bos taurus PPM1L VGNC VGNC:33216
Mus musculus PPM1L MGD MGI:2139740