2. Gene
  3. NEK10 - NIMA related kinase 10 Gene

NEK10 - NIMA related kinase 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CILD44

Gene ID: 152110 | Gene type: protein coding

About NEK10

Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38): 3:27,106,484-27,369,383 (from NCBI)

This gene has 14 transcripts (splice variants), 172 orthologues, 8 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 2.8), brain (RPKM 0.3) and 6 other tissues.

Summary

Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Apr 2022]

NEK10 Products(13)

mRNA Protein Name
NM_001031741.5 NP_001026911.1 serine/threonine-protein kinase Nek10 isoform 1
NM_001304384.3 NP_001291313.1 serine/threonine-protein kinase Nek10 isoform 4
NM_001394963.1 NP_001381892.1 serine/threonine-protein kinase Nek10 isoform 5
NM_001394964.1 NP_001381893.1 serine/threonine-protein kinase Nek10 isoform 6
NM_001394965.1 NP_001381894.1 serine/threonine-protein kinase Nek10 isoform 7
NM_001394966.1 NP_001381895.1 serine/threonine-protein kinase Nek10 isoform 8
NM_001394967.1 NP_001381896.1 serine/threonine-protein kinase Nek10 isoform 9
NM_001394968.1 NP_001381897.1 serine/threonine-protein kinase Nek10 isoform 10
NM_001394969.1 NP_001381898.1 serine/threonine-protein kinase Nek10 isoform 11
NM_001394970.1 NP_001381899.1 serine/threonine-protein kinase Nek10 isoform 2
NM_001394971.1 NP_001381900.1 serine/threonine-protein kinase Nek10 isoform 7
NM_152534.6 NP_689747.3 serine/threonine-protein kinase Nek10 isoform 2
NM_199347.4 NP_955379.2 serine/threonine-protein kinase Nek10 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein kinase activity IDA
IDA: Inferred from direct assay
20956560 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mucociliary clearance IMP
IMP: Inferred from mutant phenotype
31959991 GOA
involved in positive regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
20956560 GOA
involved in positive regulation of protein autophosphorylation IDA
IDA: Inferred from direct assay
20956560 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
20956560 GOA
involved in regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
20956560 GOA
involved in regulation of cell cycle G2/M phase transition IMP
IMP: Inferred from mutant phenotype
20956560 GOA
Cellular Component GO Annotation Evidence Reference Source
part of protein kinase complex IDA
IDA: Inferred from direct assay
20956560 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK10 Protein Structure

Pkinase

Pkinase: Protein kinase domain (519 - 779)

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  • 1172 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek10

NIMA (never in mitosis gene a)- related kinase 10

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 44

CILD44

Ciliary Dyskinesia, Primary, 44, Without Situs Inversus

Primary Ciliary Dyskinesia 44

Primary Ciliary Dyskinesia 44 Without Situs Inversus

Ciliary Dyskinesia, Primary, 44 Without Situs Inversus
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16

SCAR16

Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency

Spinocerebellar Ataxia Autosomal Recessive Type 16

Spinocerebellar Ataxia, Autosomal Recessive, 16

Ataxia, Spinocerebellar, Autosomal Recessive, Type 16
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09191 NEK10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NEK10 MGD MGI:2685128
Felis catus NEK10 VGNC VGNC:63769
Macaca mulatta NEK10 VGNC VGNC:83929
Rattus norvegicus NEK10 RGD RGD:1564342
Canis familiaris NEK10 VGNC VGNC:43730
Bos taurus NEK10 VGNC VGNC:31992