Hexb - hexosaminidase B Gene

Mus musculus

Gene ID: 15212 | Gene type: protein coding

About Hexb

Summary

Enables beta-N-acetylhexosaminidase activity and identical protein binding activity. Involved in several processes, including astrocyte cell migration; positive regulation of transcription by RNA polymerase II; and regulation of cell shape. Acts upstream of or within several processes, including ganglioside catabolic process; male courtship behavior; and penetration of zona pellucida. Located in several cellular components, including extracellular space; lysosome; and secretory granule. Is expressed in several structures, including endocrine gland; eye; genitourinary system; nervous system; and sternum. Used to study Sandhoff disease. Human ortholog(s) of this gene implicated in Sandhoff disease and spinal muscular atrophy. Orthologous to human HEXB (hexosaminidase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Hexb Products(1)

mRNA	Protein	Name
NM_010422.2	NP_034552.1	beta-hexosaminidase subunit beta precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-N-acetylhexosaminidase activity	IDA IDA: Inferred from direct assay	7203014	MGI
enables beta-N-acetylhexosaminidase activity	IGI IGI: Inferred from genetic interaction	8896570	MGI
enables beta-N-acetylhexosaminidase activity	IMP IMP: Inferred from mutant phenotype	8789434	MGI
enables hexosaminidase activity	IMP IMP: Inferred from mutant phenotype	22451654	MGI
enables hydrolase activity	IDA IDA: Inferred from direct assay	19710420	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	8269854	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in astrocyte cell migration	IMP IMP: Inferred from mutant phenotype	15155903	MGI
involved in chondroitin sulfate catabolic process	IMP IMP: Inferred from mutant phenotype	22451654	MGI
involved in dermatan sulfate catabolic process	IGI IGI: Inferred from genetic interaction	11707436	MGI
acts upstream of or within ganglioside catabolic process	IMP IMP: Inferred from mutant phenotype	8566348	MGI
acts upstream of or within glycosaminoglycan metabolic process	IGI IGI: Inferred from genetic interaction	8896570	MGI
involved in glycosaminoglycan metabolic process	IMP IMP: Inferred from mutant phenotype	11707436	MGI
acts upstream of or within glycosphingolipid metabolic process	IMP IMP: Inferred from mutant phenotype	8789434	MGI
involved in hyaluronan catabolic process	IMP IMP: Inferred from mutant phenotype	22451654	MGI
acts upstream of or within intracellular calcium ion homeostasis	IGI IGI: Inferred from genetic interaction	12756243	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	12756243	MGI
acts upstream of or within lipid storage	IGI IGI: Inferred from genetic interaction	10021458	MGI
acts upstream of or within lipid storage	IMP IMP: Inferred from mutant phenotype	7550345	MGI
acts upstream of or within locomotory behavior	IGI IGI: Inferred from genetic interaction	8896570	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	7550345	MGI
acts upstream of or within lysosome organization	IGI IGI: Inferred from genetic interaction	8896570	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	8789434	MGI
acts upstream of or within maintenance of location in cell	IMP IMP: Inferred from mutant phenotype	7550345	MGI
acts upstream of or within male courtship behavior	IMP IMP: Inferred from mutant phenotype	12617783	MGI
acts upstream of or within myelination	IGI IGI: Inferred from genetic interaction	9184660	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	7550345	MGI
acts upstream of or within neuromuscular process controlling balance	IGI IGI: Inferred from genetic interaction	8896570	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	7550345	MGI
acts upstream of or within neuron cellular homeostasis	IGI IGI: Inferred from genetic interaction	12756243	MGI
acts upstream of or within neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	12756243	MGI
acts upstream of or within oligosaccharide catabolic process	IMP IMP: Inferred from mutant phenotype	10021458	MGI
acts upstream of or within oogenesis	IMP IMP: Inferred from mutant phenotype	9223328	MGI
acts upstream of or within penetration of zona pellucida	IMP IMP: Inferred from mutant phenotype	8269854	MGI
acts upstream of or within phospholipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	15198669	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15155903	MGI
acts upstream of or within protein metabolic process	IMP IMP: Inferred from mutant phenotype	12657883	MGI
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	15155903	MGI
acts upstream of or within regulation of cellular metabolic process	IMP IMP: Inferred from mutant phenotype	15198669	MGI
acts upstream of or within sensory perception of sound	IGI IGI: Inferred from genetic interaction	8896570	MGI
acts upstream of or within sexual reproduction	IMP IMP: Inferred from mutant phenotype	9645704	MGI
involved in single fertilization	IDA IDA: Inferred from direct assay	8253842	MGI
acts upstream of or within single fertilization	IMP IMP: Inferred from mutant phenotype	12756243	MGI
acts upstream of or within skeletal system development	IGI IGI: Inferred from genetic interaction	8896570	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	8269854	MGI
located in cortical granule	IDA IDA: Inferred from direct assay	8253842	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	19710420	MGI
is active in lysosome	IDA IDA: Inferred from direct assay	8286571	MGI
located in lysosome	IDA IDA: Inferred from direct assay	11854359	MGI
is active in lysosome	IMP IMP: Inferred from mutant phenotype	22451654	MGI
located in membrane	IDA IDA: Inferred from direct assay	11854359	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beta-hexosaminidase subunit beta

N-acetyl-beta-glucosaminidase subunit beta	beta-N-acetylhexosaminidase subunit beta
hexosaminidase subunit B

Recombinant Hexb Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75808	HEXB/Hexosaminidase B Protein, Mouse (HEK293, His)	P20060 (Q32-I536)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104050	M-31850		99.94%	Unkown
HY-RS06143	HEXB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N12056	Cyclo(L-leucyl-L-valyl)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hexb	NCBI	NCBI:3074

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