2. Gene
  3. Hfe - homeostatic iron regulator Gene

Hfe - homeostatic iron regulator Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MR2

Gene ID: 15216 | Gene type: protein coding

About Hfe

Summary

Enables Transferrin Receptor binding activity. Involved in positive regulation of gene expression. Acts upstream of or within hormone biosynthetic process and multicellular organismal iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in brain; choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Used to study hemochromatosis type 1. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple); arthritis (multiple); bone marrow Cancer (multiple); hemochromatosis (multiple); and liver disease (multiple). Orthologous to human HFE (homeostatic iron regulator). [provided by Alliance of Genome Resources, Apr 2022]

Hfe Products(2)

mRNA Protein Name
NM_001347493.1 NP_001334422.1 hereditary hemochromatosis protein homolog isoform b precursor
NM_010424.5 NP_034554.2 hereditary hemochromatosis protein homolog isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables transferrin receptor binding IPI
IPI: Inferred from physical interaction
16893896 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within hormone biosynthetic process IMP
IMP: Inferred from mutant phenotype
15914561 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
10077651 MGI
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
24904118 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24904118 MGI
Cellular Component GO Annotation Evidence Reference Source
part of HFE-transferrin receptor complex IDA
IDA: Inferred from direct assay
16893896 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hereditary hemochromatosis protein homolog

hemochromatosis

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06149 HFE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18894 Hfe Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hfe NCBI NCBI:3077
Macaca fascicularis Hfe NCBI NCBI:102139119