CUX1 - cut like homeobox 1 Gene

Homo sapiens

Also known as CDP; CUX; p75; CASP; CDP1; COY1; Clox; GDDI; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317

Gene ID: 1523 | Gene type: protein coding

About CUX1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,816,007-102,283,958 (from NCBI)

This gene has 23 transcripts (splice variants), 211 orthologues, 1 paralogue and is associated with 110 phenotypes. Ubiquitous expression in endometrium (RPKM 11.3), thyroid (RPKM 8.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]

CUX1 Products(7)

mRNA	Protein	Name
NM_001202543.2	NP_001189472.1	Homeobox protein cut-like 1 isoform d
NM_001202544.3	NP_001189473.1	protein CASP isoform e
NM_001202545.3	NP_001189474.1	protein CASP isoform f
NM_001202546.3	NP_001189475.1	protein CASP isoform g
NM_001913.5	NP_001904.2	protein CASP isoform b
NM_181500.4	NP_852477.1	protein CASP isoform c
NM_181552.4	NP_853530.2	Homeobox protein cut-like 1 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15656993	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15656993	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUX1 Protein Structure

CUT

Homeobox

0
300
600
900
1200
1505 a.a.

Protein Preferred Names

Protein Names

protein CASP

Homeobox protein cut-like 1

CCAAT displacement protein

CUX1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83439	Protein CASP Antibody (YA3184)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Global Developmental Delay With Or Without Impaired Intellectual Development

GDDI

Autosomal Dominant Non-Syndromic Intellectual Disability

Leiomyoma

Leiomyomatous Neoplasm	Leiomyomatous Tumor
Leiomyomas	Fibroid Tumor
Uterine Fibroids

Leiomyoma, Uterine

Uterine Leiomyoma	Uterine Fibroid
Uterine Fibroids	Plexiform Leiomyoma
UL	Leiomyoma Of Corpus Uteri
Uterus Fibroma

Thyroid Gland Cancer

Thyroid Gland Carcinoma	Malignant Neoplasm Of Thyroid Gland
Malignant Tumour Of Thyroid Gland	Thyroid Neoplasm
Thyroid Neoplasms	Neoplasm Of Thyroid Gland
Thyroid Gland Neoplasm	Head And Neck Cancer, Thyroid
Neoplasm Of The Thyroid Gland	Cancer Of The Thyroid
Primary Malignant Neoplasm Of Thyroglossal Duct	Malignant Neoplasm Of Thyroglossal Duct
Primary Malignant Neoplasm Of Thyroid Gland	Thyroglossal Duct Cancer
Toxic Goitre Malignant Tumour	Cancerous Goitre

Uterine Corpus Endometrial Carcinoma

Myeloid And Lymphoid Neoplasms Associated With Fgfr1 Abnormalities

Thyroid Gland Medullary Carcinoma

Medullary Thyroid Carcinoma	Medullary Carcinoma Of The Thyroid Gland
Ultimobranchial Thyroid Tumor	Ultimobranchial Thyroid Tumour
Thyroid Cancer, Medullary

Multiple Endocrine Neoplasia, Type Iib

Multiple Endocrine Neoplasia Type 2b	MEN2B
Wagenmann-Froboese Syndrome	Multiple Endocrine Neoplasia Iib
Mucosal Neuroma Syndrome	Multiple Endocrine Neoplasia, Type 3
Multiple Endocrine Neoplasia, Type 2b	Men Iib
Neuromata, Mucosal, With Endocrine Tumors	Multiple Endocrine Neoplasia, Type Iii, Formerly
Men3, Formerly	Men Type Iib
Men 2b	Multiple Endocrine Neoplasia Type 3
Multiple Neoplasia 2b	Neoplasia, Endocrine, Multiple, Type Iib

Periventricular Nodular Heterotopia

Periventricular Heterotopia	Pvnh
Familial Nodular Heterotopia	Heterotopia, Periventricular
Periventricular Heterotopia, X-Linked

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03369	CUX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CUX1	RGD	RGD:620618
Macaca mulatta	CUX1	VGNC	VGNC:81298
Canis familiaris	CUX1	VGNC	VGNC:39738
Felis catus	CUX1	VGNC	VGNC:107752
Bos taurus	CUX1	VGNC	VGNC:27839
Mus musculus	CUX1	MGD	MGI:88568

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