2. Gene
  3. SLC36A2 - solute carrier family 36 member 2 Gene

SLC36A2 - solute carrier family 36 member 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PAT2; TRAMD1

Gene ID: 153201 | Gene type: protein coding

About SLC36A2

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:151,314,972-151,347,559 (from NCBI)

This gene has 6 transcripts (splice variants), 276 orthologues, 15 paralogues and is associated with 3 phenotypes. Restricted expression toward kidney (RPKM 31.7).

Summary

This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid Auxin permease 1 protein family. The encoded protein primarily transports small Amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]

SLC36A2 Products(1)

mRNA Protein Name
NM_181776.3 NP_861441.2 proton-coupled amino acid transporter 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables amino acid:proton symporter activity IDA
IDA: Inferred from direct assay
12809675 GOA
enables proline:proton symporter activity IDA
IDA: Inferred from direct assay
12809675 GOA
Biological Process GO Annotation Evidence Reference Source
involved in proline transmembrane transport IMP
IMP: Inferred from mutant phenotype
19033659 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
19033659 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC36A2 Protein Structure

Aa_trans

Aa_trans: Transmembrane amino acid transporter protein (53 - 462)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 483 a.a.
Protein Preferred Names Protein Names

proton-coupled amino acid transporter 2

solute carrier family 36 (proton/amino acid symporter), member 2

Related Diseases

Diseases Alias
Iminoglycinuria

Iminoglycinuria, Digenic

IG
Hyperglycinuria

Glycinuria With Or Without Oxalate Urolithiasis

Glycinuria With Or Without Oxalate Nephrolithiasis

Iminoglycinuria Type Ii

HG
Otosalpingitis

Eustachian Salpingitis

Eustachian Tube Salpingitis

Rhinosalpingitis

Tubotympanitis

Eustachian Tube Inflammation

Salpingitis Of Ear
Eustachian Tube Disease

Eustachian Tube Disorder

Auditory Tube Disorder

Disease Of Eustachian Tube

Eustachian Tube Dysfunction

Et- [Eustachian Tube Disorder]

Etd - [Eustachian Tube Dysfunction]
Non-Suppurative Otitis Media

Nonsuppurative Otitis Media
Epidemic Typhus

Typhus

Typhus Fever

Epidemic Louse-Borne Typhus Fever Due To Rickettsia Prowazekii

Murine Typhus

Classical Typhus

Endemic Flea-Borne Typhus

Endemic Typhus Fever

Epidemic Louse-Borne Typhus

Famine Fever

Flea-Borne Typhus

Jail Fever

Louse-Borne Typhus

Mexican Typhus

Shop Typhus

Urban Typhus

Brill-Zinsser Disease

Endemic Typhus

Sylvatic Typhus

Epidemic Typhus

European Typhus

Exanthematic Typhus Fever

Exanthematous Typhus

Flea Typhus

Flea-Borne Rickettsiosis

Hospital Fever

Louse-Borne [Epidemic] Typhus

Louse-Borne Rickettsiosis

Moscow Typhus

Murine [Endemic] Typhus

Petechial Fever

Prison Fever

Rat Flea Typhus

Ship Fever

Typhus Exanthematique

Typhus, Endemic Flea-Borne

Typhus, Epidemic Louse-Borne

Typhus Group Rickettsial Disease

Relapsing Fever

Typhus Fever Nos

Typhus Nos

Epidemic Typhus Fever

Louse-Borne Typhus Fever

Classical Typhus Fever

Louse-Borne Tabardillo

Epidemic Typhus Fever Due To Rickettsia Prowazekii

Endemic Murine Typhus

Flea-Borne Typhus Fever

Murine Endemic Flea Typhus

Rat Typhus

Typhus Due To Rickettsia Typhi

Flea-Borne Tabardillo

Rickettsia Typhi Rickettsiosis

Mexican Fever

Murine Flea-Borne Typhus

Mooser Bodies

Tsutsugamushi Fever

Kedani Fever

Mite-Borne Typhus

Mite-Borne Typhus Due To Rickettsia Tsutsugamushi

Scrub Typhus

Tsutsugamushi

Tsutsugamushi Disease

Scrub Mite-Borne Typhus

Sumatran Mite Fever

Japanese River Fever

Kedani Typhus

Rickettsia Tsutsugamushi Rickettsiosis

Sumatran Mite Typhus

Tropical Typhus

Japanese Typhus
Nephrotic Syndrome, Type 22

NPHS22

Nephrotic Syndrome Type 22

Nephrotic Syndrome 22
Queensland Tick Typhus

Australian Tick Typhus

North Queensland Tick Typhus

Rickettsia Australis Spotted Fever
Brill-Zinsser Disease

Recrudescent Typhus

Brill Disease

Brill Zinsser Disease

Brill'S Disease

Latent Typhus

Sporadic Typhus

Typhus, Epidemic Louse-Borne

Recrudescent Typhus Due To Rickettsia Prowazekii

Recrudescent Typhus Fever

Recrudescent Brill-Zinsser Typhus Due To Rickettsia Prowazekii

Recrudescent Brill Disease

Recrudescent Typhus Fever Due To Rickettsia Prowazekii
Digenic Disease
Retinitis Pigmentosa 68

RP68

Retinitis Pigmentosa, Type 68
Endemic Typhus

Murine Typhus

Cat Flea Rickettsiosis

Fleaborne Typhus

Rat-Flea Typhus

Rickettsia Felis Spotted Fever

Shop Typhus

Toulon Typhus

Urban Typhus

Urban Typhus Of Malaya

Flea-Borne Typhus

Endemic Flea-Borne Typhus
Nephrotic Syndrome, Type 21

NPHS21

Nephrotic Syndrome Type 21

Nephrotic Syndrome 21
Japanese Spotted Fever

Oriental Spotted Fever

Rickettsia Japonica Spotted Fever
Spinal Muscular Atrophy, Type Iv

SMA4

Spinal Muscular Atrophy, Adult Form

Spinal Muscular Atrophy 4

Spinal Muscular Atrophy-4

Adult Spinal Muscular Atrophy

Spinal Muscular Atrophy, Proximal, Adult, Autosomal Recessive

Proximal Spinal Muscular Atrophy Type 4

Sma Type 4

Sma Type Iv

Sma-Iv

Sma Iv

Spinal Muscular Atrophy Adult Form

Spinal Muscular Atrophy Proximal Adult Autosomal Recessive

Spinal Muscular Atrophy Type Iv

Atrophy, Muscular, Spinal, Type Iv

Myelopathic Muscular Atrophy
Rocky Mountain Spotted Fever

Brazillian Spotted

Choix

Exanthematic Typhus Of Sao Paulo

Fiebre Maculosa

Fiebre Manchada

Sao Paulo Typhus

So Paulo Fever

Tick Typhus

Tobia Fever

Rmsf

Typhus, Tick
Vestibulocochlear Nerve Disease

Vestibulocochlear Nerve Diseases

Acoustic Nerve Disease

Cochlear Nerve Diseases

Disturbance Of Vestibulocochlear Nerve

Auditory Nerve Disorder

Disorder Of Acoustovestibular Nerve

Disorder Of Eighth Nerve

Eighth Cranial Nerve Disorder

Disease Of Eighth Cranial Nerve

Disease Of Acoustic Nerve

Disease Of Auditory Nerve

Disorder Of 8th Cranial Nerve

Auditory Nerve Lesion

Cochlear Nerve Disorder
Vestibular Neuronitis

Vestibular Neuritis

Epidemic Neurolabyrinthitis
Spinal Muscular Atrophy, Type Iii

SMA3

Juvenile Spinal Muscular Atrophy

Kugelberg-Welander Disease

Sma Iii

Kugelberg-Welander Syndrome

Kws

Muscular Atrophy, Juvenile

Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

Spinal Muscular Atrophy-3

Spinal Muscular Atrophy Type 3

Spinal Muscular Atrophy, Type Iii, Modifier Of

Type Iii Spinal Muscular Atrophy

Sma 3

Proximal Spinal Muscular Atrophy Type 3

Sma Type 3

Sma Type Iii

Sma-Iii

Spinal Muscular Atrophy 3

Spinal Muscular Atrophy Mild Childhood And Adolescent Form

Spinal Muscular Atrophy Type Iii

Wohlfart-Kugelberg-Welander Disease

Atrophy, Muscular, Spinal, Type Iii
Spinal Muscular Atrophy, Type Ii

SMA2

Sma Ii

Muscular Atrophy, Spinal, Intermediate Type

Muscular Atrophy, Spinal, Infantile Chronic Form

Intermediate Spinal Muscular Atrophy

Spinal Muscular Atrophy Type Ii

Spinal Muscular Atrophy-2

Spinal Muscular Atrophy 2

Spinal Muscular Atrophy Type 2

Dubowitz Disease

Proximal Spinal Muscular Atrophy Type 2

Sma Type 2

Sma Type Ii

Sma-Ii

Spinal Muscular Atrophy Infantile Chronic Form

Spinal Muscular Atrophy Intermediate Type

Spinal Muscular Atrophies Of Childhood

Atrophy, Muscular, Spinal, Type Ii

Muscular Atrophy, Spinal, Type Ii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13211 SLC36A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC36A2 MGD MGI:1891430
Macaca mulatta SLC36A2 VGNC VGNC:77510
Bos taurus SLC36A2 VGNC VGNC:34839
Canis familiaris SLC36A2 VGNC VGNC:46383
Rattus norvegicus SLC36A2 RGD RGD:620492