ARSK - arylsulfatase family member K Gene

Homo sapiens

Also known as MPS10; TSULF

Gene ID: 153642 | Gene type: protein coding

About ARSK

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:95,555,101-95,605,102 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 16 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 2.9), ovary (RPKM 2.9) and 25 other tissues.

Summary

Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated Steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

ARSK Products(1)

mRNA	Protein	Name
NM_198150.3	NP_937793.1	arylsulfatase K precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables arylsulfatase activity	IMP IMP: Inferred from mutant phenotype	23986440	GOA
enables glucuronate-2-sulfatase activity	IMP IMP: Inferred from mutant phenotype	28055182	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	23986440	GOA
located in lysosome	IDA IDA: Inferred from direct assay	23986440	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARSK Protein Structure

Sulfatase

0
100
200
300
400
500
536 a.a.

Protein Preferred Names

Protein Names

arylsulfatase K

ASK

Related Diseases

Diseases

Alias

Mucopolysaccharidosis, Type X

MPS10	Arsk Deficiency
Arylsulfatase K Deficiency	Mucopolysaccharidosis 10
Arlysulfatase K Deficiency	Mucopolysaccharidosis, Type 10

Gastric Dilatation

Stomach Dilatation

Metachromatic Leukodystrophy

Arylsulfatase A Deficiency	MLD
Arsa Deficiency	Sulfatide Lipidosis
Metachromatic Leukoencephalopathy	Cerebral Sclerosis, Diffuse, Metachromatic Form
Cerebroside Sulfatase Deficiency	Leukodystrophy, Metachromatic
Pseudoarylsulfatase A Deficiency	Leukodystrophy Metachromatic
Sulfatidosis	Metachromatic Leukodystrophy, Late Infantile
Metachromatic Leukodystrophy Variant	Deficiency Of Cerebroside-Sulfatase
Scholz Cerebral Sclerosis	Sulfatide Lipoidosis
Cerebral Sclerosis Diffuse Metachromatic Form	Arylsulfatase A Deficiency Disease
Cerebroside Sulphatase Deficiency Disease	Greenfield Disease
Metachromatic Leukodystrophy, Adult	Metachromatic Leukodystrophy, Juvenile
Leukodystrophy Metachromatic Adult	Leukodystrophy Metachromatic Juvenile
Leukodystrophy Metachromatic Late Infantile	Metachromatic Leukodystrophy, Adult Type
Metachromatic Leukodystrophy, Juvenile Type	Metachromatic Leukodystrophy, Infant
Greenfield'S Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01042	ARSK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARSK	MGD	MGI:1924291
Bos taurus	ARSK	VGNC	VGNC:26179
Macaca mulatta	ARSK	VGNC	VGNC:84280
Canis familiaris	ARSK	VGNC	VGNC:38146
Felis catus	ARSK	VGNC	VGNC:59949
Rattus norvegicus	ARSK	RGD	RGD:1310182

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