2. Gene
  3. Hmox1 - heme oxygenase 1 Gene

Hmox1 - heme oxygenase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HO1; HO-1; Hmox; Hemox; Hsp32; D8Wsu38e

Gene ID: 15368 | Gene type: protein coding

About Hmox1

Summary

Predicted to enable several functions, including heme binding activity; heme oxygenase (decyclizing) activity; and protein homodimerization activity. Acts upstream of or within several processes, including cellular response to cisplatin; cellular response to metal ion; and regulation of macroautophagy. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study hemochromatosis and malaria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); Factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to human HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hmox1 Products(1)

mRNA Protein Name
NM_010442.2 NP_034572.1 heme oxygenase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32973183 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to arsenic-containing substance IDA
IDA: Inferred from direct assay
12220541 MGI
acts upstream of or within cellular response to cadmium ion IDA
IDA: Inferred from direct assay
16183037 MGI
acts upstream of or within cellular response to cisplatin IMP
IMP: Inferred from mutant phenotype
20705711 MGI
acts upstream of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20705711 MGI
acts upstream of or within heme catabolic process IGI
IGI: Inferred from genetic interaction
31571584 MGI
acts upstream of or within heme metabolic process IDA
IDA: Inferred from direct assay
16183037 MGI
acts upstream of macroautophagy IMP
IMP: Inferred from mutant phenotype
20705711 MGI
acts upstream of or within negative regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
20705711 MGI
acts upstream of or within positive regulation of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20705711 MGI
acts upstream of or within positive regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
20705711 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cytosol IGI
IGI: Inferred from genetic interaction
31571584 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17430897 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heme oxygenase 1

P32 protein

heme oxygenase (decycling) 1

hemoxygenase

Recombinant Hmox1 Proteins

Cat. No. Product Name Accession Purity
HY-P700495 HO-1 Protein, Mouse (His) P14901 (M1-M289) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0643 Carnosol 99.90% Unkown
HY-121523 MIND4-17 Activator 99.93% Unkown
HY-124815 CP-312 Inducer 99.69% Unkown
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% Unkown
HY-RS06249 HMOX1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-149245 Keap1-Nrf2-IN-15 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmox1 NCBI NCBI:3162