Hrh2 - histamine receptor H2 Gene

Mus musculus

Also known as H2R; HH2R

Gene ID: 15466 | Gene type: protein coding

About Hrh2

Chromosome 13: 54,346,148-54,390,199 forward strand.GRCm39:CM001006.3

This gene has 3 transcripts (splice variants), 249 orthologues, 32 paralogues and is associated with 15 phenotypes. Broad expression in frontal lobe adult (RPKM 1.9), stomach adult (RPKM 1.8) and 18 other tissues.

Summary

Predicted to enable G protein-coupled amine receptor activity; heterocyclic compound binding activity; and neurotransmitter receptor activity. Acts upstream of or within several processes, including gastric acid secretion; learning or memory; and toxin transport. Predicted to be located in membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in brain; early conceptus; stomach; and uterus. Orthologous to human HRH2 (Histamine Receptor H2). [provided by Alliance of Genome Resources, Apr 2022]

Hrh2 Products(2)

mRNA	Protein	Name
NM_001413010.1	NP_001399939.1	histamine H2 receptor isoform 3
NM_001010973.3	NP_001010973.1	histamine H2 receptor isoform 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	10862789	MGI
acts upstream of or within epithelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	10862789	MGI
acts upstream of or within gastric acid secretion	IGI IGI: Inferred from genetic interaction	15476751	MGI
acts upstream of or within gastrin-induced gastric acid secretion	IMP IMP: Inferred from mutant phenotype	10862789	MGI
acts upstream of or within gland development	IMP IMP: Inferred from mutant phenotype	15476751	MGI
acts upstream of or within histamine-induced gastric acid secretion	IMP IMP: Inferred from mutant phenotype	10862789	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	17145090	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17145090	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	17145090	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hrh2 Protein Structure

7tmA_Histamine_H2R

0
100
200
300
397 a.a.

Protein Preferred Names

Protein Names

histamine H2 receptor

gastric receptor I

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06362	HRH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06363	Hrh2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06364	Hrh2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hrh2	NCBI	NCBI:3274

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