2. Gene
  3. LINGO2 - leucine rich repeat and Ig domain containing 2 Gene

LINGO2 - leucine rich repeat and Ig domain containing 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LERN3; LRRN6C

Gene ID: 158038 | Gene type: protein coding

About LINGO2

Cytogenetic location: 9p21.2-p21.1 Genomic coordinates (GRCh38): 9:27,937,617-29,213,601 (from NCBI)

This gene has 9 transcripts (splice variants), 274 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

LINGO2 Products(4)

mRNA Protein Name
NM_001258282.3 NP_001245211.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor
NM_001354574.2 NP_001341503.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor
NM_001354575.2 NP_001341504.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor
NM_152570.4 NP_689783.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor

LINGO2 Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (27 - 56)

LRR_8

LRR_8: Leucine rich repeat (106 - 165)

LRR_1

LRR_1: Leucine Rich Repeat (275 - 296)

LRR_8

LRR_8: Leucine rich repeat (298 - 357)

I-set

I-set: Immunoglobulin I-set domain (415 - 500)

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  • 606 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2

leucine rich repeat neuronal 6C

Related Diseases

Diseases Alias
Essential Tremor

Benign Essential Tremor

Familial Tremor

Hereditary Essential Tremor

Essential Hereditary Tremor

Shaky Hand Syndrome

Benign Essential Tremor Syndrome

Tremor Hereditary Essential

Essential Tremor, Susceptibility To

Tremor, Hereditary Essential
Tremor, Hereditary Essential, 5

ETM5

Essential Tremor 5

Essential Tremor, Hereditary, 5

Hereditary Essential Tremor 5

Tremor, Hereditary Essential 5

Tremor, Essential Hereditary, Type 5
Tremor, Hereditary Essential, 4

ETM4

Essential Tremor 4

Essential Tremor, Hereditary, 4

Hereditary Essential Tremor 4

Tremor, Hereditary Essential 4

Tremor, Hereditary Essential, Type 4
Tremor, Hereditary Essential, 1

ETM1

Fet1

Essential Tremor 1

Tremor, Familial Essential, 1

Essential Tremor, Hereditary, 1

Hereditary Essential Tremor 1

Tremor Hereditary Essential, 1

Tremor Familial Essential, 1

Tremor, Hereditary Essential 1

Tremor, Essential Hereditary, Type 1
Ectodermal Dysplasia 14, Hair/Tooth Type With Or Without Hypohidrosis

ECTD14

Ectodermal Dysplasia 14

Ectn14
Motion Sickness

Airsickness

Carsickness

Seasickness

Travel Sickness

Riders' Vertigo
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07681 LINGO2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LINGO2 VGNC VGNC:63237
Canis familiaris LINGO2 VGNC VGNC:42689
Rattus norvegicus LINGO2 RGD RGD:1310773
Bos taurus LINGO2 VGNC VGNC:30900
Mus musculus LINGO2 MGD MGI:2442298
Macaca mulatta LINGO2 VGNC VGNC:74095