Igfbp5 - insulin-like growth factor binding protein 5 Gene

Mus musculus

Also known as IGFBP-5; IGFBP-5P

Gene ID: 16011 | Gene type: protein coding

About Igfbp5

Summary

Enables fibronectin binding activity and insulin-like growth factor binding activity. Involved in several processes, including female pregnancy; lung alveolus development; and negative regulation of skeletal muscle hypertrophy. Acts upstream of or within several processes, including hair follicle morphogenesis; negative regulation of osteoblast differentiation; and regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be part of insulin-like growth factor ternary complex. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; embryo ectoderm; impulse conducting system; limb; and metanephros. Orthologous to human IGFBP5 (Insulin like growth factor binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Igfbp5 Products(1)

mRNA	Protein	Name
NM_010518.2	NP_034648.2	insulin-like growth factor-binding protein 5 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibronectin binding	IDA IDA: Inferred from direct assay	19236847	MGI
enables insulin-like growth factor binding	IPI IPI: Inferred from physical interaction	14566968	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	15010534	MGI
acts upstream of or within glucose homeostasis	IGI IGI: Inferred from genetic interaction	16675541	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	19897600	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	16024235	MGI
acts upstream of insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16024235	MGI
involved in lung alveolus development	IMP IMP: Inferred from mutant phenotype	15010534	MGI
acts upstream of or within mammary gland involution	IMP IMP: Inferred from mutant phenotype	17255210	MGI
involved in negative regulation of growth	IMP IMP: Inferred from mutant phenotype	15010534	MGI
acts upstream of or within negative regulation of insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16024235	MGI
involved in negative regulation of muscle tissue development	IMP IMP: Inferred from mutant phenotype	15010534	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	19208758	MGI
involved in negative regulation of skeletal muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	15010534	MGI
involved in osteoblast differentiation	IEP IEP: Inferred from expression pattern	16311053	MGI
acts upstream of or within positive regulation of insulin-like growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	16675541	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18762576	MGI
acts upstream of or within regulation of cell growth	IGI IGI: Inferred from genetic interaction	16675541	MGI
acts upstream of or within regulation of growth	IGI IGI: Inferred from genetic interaction	16675541	MGI
acts upstream of or within striated muscle cell differentiation	IGI IGI: Inferred from genetic interaction	18762576	MGI
acts upstream of or within striated muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	18762576	MGI
acts upstream of or within type B pancreatic cell proliferation	IGI IGI: Inferred from genetic interaction	16675541	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

insulin-like growth factor-binding protein 5

IBP-5

IGF-binding protein 5

Recombinant Igfbp5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70408	IGFBP-5 Protein, Mouse (HEK293, His)	Q07079 (L20-E271)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06628	IGFBP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Igfbp5	NCBI	NCBI:3488
Canis familiaris	Igfbp5	NCBI	NCBI:610316

Name
Email *

	Sorry, but the email address you supplied was invalid.