DAD1 - defender against cell death 1 Gene

Homo sapiens

Also known as OST2

Gene ID: 1603 | Gene type: protein coding

About DAD1

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,564,907-22,589,224 (from NCBI)

This gene has 5 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in thyroid (RPKM 108.7), adrenal (RPKM 94.4) and 25 other tissues.

Summary

DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered Apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified Enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]

DAD1 Products(1)

mRNA	Protein	Name
NM_001344.4	NP_001335.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme activator activity	IMP IMP: Inferred from mutant phenotype	22467853	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein N-linked glycosylation	IDA IDA: Inferred from direct assay	31831667	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: Inferred from mutant phenotype	22467853	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	22467853	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of oligosaccharyltransferase complex	IDA IDA: Inferred from direct assay	22467853	GOA
part of oligosaccharyltransferase complex	IPI IPI: Inferred from physical interaction	31831667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAD1 Protein Structure

DAD

0
100
113 a.a.

Protein Preferred Names

Protein Names

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

DAD-1

Related Diseases

Diseases

Alias

Ogden Syndrome

OGDNS	N-Terminal Acetyltransferase Deficiency
NATD	N-Alpha-Acetyltransferase
X-Linked Malformation And Infantile Lethality Syndrome	Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03518	DAD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DAD1	VGNC	VGNC:27870
Felis catus	DAD1	VGNC	VGNC:61331
Rattus norvegicus	DAD1	RGD	RGD:621028
Mus musculus	DAD1	MGD	MGI:101912
Macaca mulatta	DAD1	VGNC	VGNC:71727

Name
Email *

	Sorry, but the email address you supplied was invalid.