DENND5B - DENN domain containing 5B Gene

Homo sapiens

Gene ID: 160518 | Gene type: protein coding

About DENND5B

Cytogenetic location: 12p11.21 Genomic coordinates (GRCh38): 12:31,382,226-31,591,136 (from NCBI)

This gene has 7 transcripts (splice variants), 188 orthologues and 10 paralogues. Broad expression in ovary (RPKM 8.9), testis (RPKM 6.8) and 21 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of triglyceride transport and regulation of catalytic activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

DENND5B Products(6)

mRNA	Protein	Name
NM_001308339.2	NP_001295268.1	DENN domain-containing protein 5B isoform 2
NM_001366890.1	NP_001353819.1	DENN domain-containing protein 5B isoform 3
NM_001366891.1	NP_001353820.1	DENN domain-containing protein 5B isoform 4
NM_001366892.1	NP_001353821.1	DENN domain-containing protein 5B isoform 5
NM_001366893.1	NP_001353822.1	DENN domain-containing protein 5B isoform 6
NM_144973.4	NP_659410.3	DENN domain-containing protein 5B isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	20937701	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DENND5B Protein Structure

uDENN

DENN

dDENN

RUN

PLAT

RUN

0
200
400
600
800
1000
1200
1274 a.a.

Protein Preferred Names

Protein Names

DENN domain-containing protein 5B

DENN/MADD domain containing 5B

Related Diseases

Diseases

Alias

Lissencephaly 8

LIS8

Spinocerebellar Ataxia, Autosomal Recessive 24

SCAR24	Autosomal Recessive Spinocerebellar Ataxia 24
Spinocerebellar Ataxia, Autosomal Recessive, 24	Ataxia, Spinocerebellar, Autosomal Recessive, Type 24

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03691	DENND5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DENND5B	VGNC	VGNC:39894
Rattus norvegicus	DENND5B	RGD	RGD:2318606
Mus musculus	DENND5B	MGD	MGI:2444273
Macaca mulatta	DENND5B	VGNC	VGNC:71772
Bos taurus	DENND5B	VGNC	VGNC:28002
Felis catus	DENND5B	VGNC	VGNC:61440

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