DGKG - diacylglycerol kinase gamma Gene

Homo sapiens

Also known as DAGK3; DGK-GAMMA

Gene ID: 1608 | Gene type: protein coding

About DGKG

Cytogenetic location: 3q27.2-q27.3 Genomic coordinates (GRCh38): 3:186,147,201-186,362,234 (from NCBI)

This gene has 11 transcripts (splice variants), 224 orthologues and 9 paralogues. Broad expression in brain (RPKM 8.0), heart (RPKM 3.6) and 15 other tissues.

Summary

This gene encodes an Enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These Enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DGKG Products(3)

mRNA	Protein	Name
NM_001080744.2	NP_001074213.1	diacylglycerol kinase gamma isoform 2
NM_001080745.2	NP_001074214.1	diacylglycerol kinase gamma isoform 3
NM_001346.3	NP_001337.2	diacylglycerol kinase gamma isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-dependent diacylglycerol kinase activity	IDA IDA: Inferred from direct assay	8034597	GOA
enables lipid binding	IDA IDA: Inferred from direct assay	22627129	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in diacylglycerol metabolic process	IDA IDA: Inferred from direct assay	8034597	GOA
involved in glycerolipid metabolic process	IDA IDA: Inferred from direct assay	22627129	GOA
involved in lipid phosphorylation	IDA IDA: Inferred from direct assay	8034597	GOA
involved in phosphatidic acid biosynthetic process	IDA IDA: Inferred from direct assay	8034597	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	8034597	GOA
located in membrane	IDA IDA: Inferred from direct assay	8034597	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKG Protein Structure

DAG_kinase_N

EF-hand_7

C1_1

DAGK_cat

DAGK_acc

0
200
400
600
791 a.a.

Protein Preferred Names

Protein Names

diacylglycerol kinase gamma

DAG kinase gamma

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 14

Spinocerebellar Ataxia Type 14	SCA14
Ataxia, Spinocerebellar, Type 14

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03719	DGKG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DGKG	VGNC	VGNC:28028
Canis familiaris	DGKG	VGNC	VGNC:39919
Mus musculus	DGKG	MGD	MGI:105060
Macaca mulatta	DGKG	VGNC	VGNC:71785
Felis catus	DGKG	VGNC	VGNC:97399
Rattus norvegicus	DGKG	RGD	RGD:2499

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