DGKH - diacylglycerol kinase eta Gene

Homo sapiens

Also known as DGKeta

Gene ID: 160851 | Gene type: protein coding

About DGKH

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:42,040,070-42,256,584 (from NCBI)

This gene has 10 transcripts (splice variants), 220 orthologues and 9 paralogues. Ubiquitous expression in endometrium (RPKM 2.6), placenta (RPKM 1.9) and 24 other tissues.

Summary

This gene encodes a member of the diacylglycerol kinase (DGK) Enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014]

DGKH Products(6)

mRNA	Protein	Name
NM_001204504.3	NP_001191433.1	diacylglycerol kinase eta isoform 1
NM_001204505.3	NP_001191434.1	diacylglycerol kinase eta isoform 3
NM_001204506.3	NP_001191435.1	diacylglycerol kinase eta isoform 4
NM_001297429.2	NP_001284358.1	diacylglycerol kinase eta isoform 5
NM_152910.6	NP_690874.2	diacylglycerol kinase eta isoform 1
NM_178009.5	NP_821077.1	diacylglycerol kinase eta isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-dependent diacylglycerol kinase activity	IDA IDA: Inferred from direct assay	23949095	GOA
enables ATP-dependent diacylglycerol kinase activity	IMP IMP: Inferred from mutant phenotype	12810723	GOA
enables SAM domain binding	IDA IDA: Inferred from direct assay	12810723	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	12810723	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	12810723	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phosphatidic acid metabolic process	IDA IDA: Inferred from direct assay	23949095	GOA
involved in phospholipase C/protein kinase C signal transduction	IMP IMP: Inferred from mutant phenotype	12810723	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12810723	GOA
located in endosome	IDA IDA: Inferred from direct assay	12810723	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	12810723	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKH Protein Structure

C1_1

DAGK_cat

DAGK_acc

SAM_2

0
200
400
600
800
1000
1220 a.a.

Protein Preferred Names

Protein Names

diacylglycerol kinase eta

DAG kinase eta

Related Diseases

Diseases

Alias

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Nephrolithiasis

Kidney Stones	Stone - Kidney/Ureter
Kidney Calculi

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03720	DGKH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DGKH	VGNC	VGNC:61460
Canis familiaris	DGKH	VGNC	VGNC:39920
Macaca mulatta	DGKH	VGNC	VGNC:71786
Bos taurus	DGKH	VGNC	VGNC:28029
Rattus norvegicus	DGKH	RGD	RGD:1561955
Mus musculus	DGKH	MGD	MGI:2444188

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