STOML3 - stomatin like 3 Gene

Homo sapiens

Also known as SRO; Epb7.2l

Gene ID: 161003 | Gene type: protein coding

About STOML3

Cytogenetic location: 13q13.3 Genomic coordinates (GRCh38): 13:38,965,925-38,990,831 (from NCBI)

This gene has 2 transcripts (splice variants), 276 orthologues and 4 paralogues. Biased expression in lung (RPKM 1.0), endometrium (RPKM 0.3) and 2 other tissues.

Summary

Predicted to act upstream of or within signal transduction. Predicted to be located in cilium and membrane raft. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

STOML3 Products(2)

mRNA	Protein	Name
NM_001144033.2	NP_001137505.1	stomatin-like protein 3 isoform 2
NM_145286.3	NP_660329.1	stomatin-like protein 3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STOML3 Protein Structure

Band_7

0
100
200
291 a.a.

Protein Preferred Names

Protein Names

stomatin-like protein 3

EPB72-like 3

STOML3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STOML3	Q8TAV4	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Overhydrated Hereditary Stomatocytosis

Ohs	Potassium Sodium Disorder Of Erythrocyte
OHST	Stomatocytosis I
Potassium-Sodium Disorder Of Erythrocyte	Stomatocytosisiohst
Hereditary, Overhydrated, Cation-Leak Stomatocytosis	Overhydrated Cation Leak Stomatocytosis
Stomatocytosis, Overhydrated Hereditary

Oculomotor Nerve Paralysis

Iii Nerve Palsy	Iiird Nerve Paralysis
Third Cranial Nerve Paralysis

Herpes Zoster Oticus

Nervus Intermedius Neuralgia	Ramsay Hunt Syndrome Type 2
Geniculate Herpes Zoster	Geniculate Neuralgia
Herpes Zoster Auricularis	Herpetic Geniculate Ganglionitis
Ramsay Hunt Syndrome Type Ii	Ramsey Hunt Syndrome
Facial Nerve Palsy Due To Vzv	Facial Nerve Palsy Due To Herpes Zoster Infection
Facial Nerve Paralysis Due To Vzv	Hunt Syndrome
Hunt'S Syndrome	Ramsay Hunt Syndrome
Myoclonus And Ataxia

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Abducens Palsy

Sixth Nerve Palsy	Abducens Nerve Palsy
Abducens Nerve Disease	Abducens Nerve Weakness
Lateral Rectus Muscle Denervation Paresis	Lateral Rectus Muscle Innervation Disorder
Sixth Cranial Nerve Disorder	6th Nerve Palsy
Abducens Nerve Diseases	Vith Nerve Disorder
Vith Nerve Paralysis	Cranial Mononeuropathy Vi
Cranial Nerve Vi Palsy	Sixth Cranial Nerve Palsy
Vi Nerve Palsy	Abducens Nerve Disorder
Abducens Sixth Nerve Palsy	Abducens Nerve Paralysis
Disease Or Disorder Of Abducent Nerve	Sixth Cranial Nerve Disease
Sixth Cranial Nerve Weakness	Disorder Of Sixth Cranial Nerve
Isolated Abducent Nerve Palsy	Atrophy Of Sixth Cranial Nerve
Paralysis Of Sixth Cranial Nerve

Facial Neuralgia

Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema

Dehydrated Hereditary Stomatocytosis	Hereditary Xerocytosis
Xerocytosis, Hereditary	Pshk1
Pseudohyperkalemia Edinburgh	Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema
DHS1	Dhs
Hereditary Desiccytosis	Dehydrated Hereditary Stomatocytosis 1
Desiccytosis, Hereditary	Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak
Pseudohyperkalemia Familial 1, Due To Red Cell Leak	Desiccytosis Hereditary
Xerocytosis Hereditary	Familial Pseudohyperkalemia 1 Due To Red Cell Leak
Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema	Xerocytosis

Third Cranial Nerve Disease

Disorder Of Oculomotor Nerve	Oculomotor Nerve Disorder
Oculomotor Nerve Paralysis	Third Cranial Nerve Disorder

Intracranial Hypotension

Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome	Spiegler-Brooke Syndrome
Familial Cylindromatosis	BRSS
Bss	Sbs
Multiple Familial Trichoepithelioma	Ancell-Spiegler Cylindromas
Familial Multiple Trichoepithelioma	Trichoepithelioma
Fc	Mft
Multiple Familial Trichoepitheliomas	Ccs
Turban Tumor Syndrome	Schilbach-Rott Syndrome
Eccrine Dermal Cylindroma	Familial Multiple Trichoepitheliomata

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122671	OB-1	Inhibitor	99.12%	Unkown
HY-122671S	OB-1-d3	Control	/	Unkown
HY-RS13951	STOML3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119519	OB-2		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STOML3	MGD	MGI:2388072
Rattus norvegicus	STOML3	RGD	RGD:1311090
Bos taurus	STOML3	VGNC	VGNC:35412
Macaca mulatta	STOML3	VGNC	VGNC:78170
Canis familiaris	STOML3	VGNC	VGNC:46932
Felis catus	STOML3	VGNC	VGNC:65795

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