Ikbkb - inhibitor of kappaB kinase beta Gene

Mus musculus

Also known as IKK2; IKK-2; IKK[b]; IKKbeta; IKK-beta

Gene ID: 16150 | Gene type: protein coding

About Ikbkb

Chromosome 8: 23,149,228-23,196,605 reverse strand.GRCm39:CM001001.3

This gene has 14 transcripts (splice variants), 198 orthologues, 3 paralogues and is associated with 32 phenotypes. Ubiquitous expression in spleen adult (RPKM 15.9), thymus adult (RPKM 12.5) and 28 other tissues.

Summary

Enables IkappaB kinase activity and protein Phosphatase binding activity. Involved in peptidyl-serine phosphorylation and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within B cell homeostasis; positive regulation of cation channel activity; and positive regulation of sodium ion transport. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including genitourinary system and musculature. Used to study immunodeficiency 15A. Human ortholog(s) of this gene implicated in breast cancer; combined immunodeficiency (multiple); dermatitis; prostate Cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Ikbkb Products(2)

mRNA	Protein	Name
NM_001159774.1	NP_001153246.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1
NM_010546.2	NP_034676.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables IkappaB kinase activity	IDA IDA: Inferred from direct assay	18981174	MGI
enables IkappaB kinase activity	IMP IMP: Inferred from mutant phenotype	10229185	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	15684432	MGI
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	12235208	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	17954568	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	25326420	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell homeostasis	IMP IMP: Inferred from mutant phenotype	12235208	MGI
involved in canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	20434986	MGI
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	10229185	MGI
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	36812915	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	25326420	MGI
acts upstream of or within positive regulation of cation channel activity	IGI IGI: Inferred from genetic interaction	18981174	MGI
acts upstream of or within positive regulation of sodium ion transport	IGI IGI: Inferred from genetic interaction	18981174	MGI
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	15084260	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of CD40 receptor complex	IDA IDA: Inferred from direct assay	20614026	MGI
part of IkappaB kinase complex	IDA IDA: Inferred from direct assay	10229185	MGI
part of IkappaB kinase complex	IPI IPI: Inferred from physical interaction	20434986	MGI
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	20614026	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ikbkb Protein Structure

STKc_IKK_beta

Ubl_IKKA_like

IKBKB_SDD

IKKbetaNEMObind

0
200
400
600
757 a.a.

Protein Preferred Names

Protein Names

inhibitor of nuclear factor kappa-B kinase subunit beta

I-kappa-B kinase 2	I-kappa-B-kinase beta
IKK-B	NFKBIKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	nuclear factor NF-kappa-B inhibitor kinase beta
serine/threonine protein kinase IKBKB

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06659	Ikbkb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06658	IKBKB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06660	Ikbkb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ikbkb	NCBI	NCBI:3551

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