EXD1 - exonuclease 3'-5' domain containing 1 Gene

Homo sapiens

Also known as EXDL1

Gene ID: 161829 | Gene type: protein coding

About EXD1

This gene has 5 transcripts (splice variants), 182 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 6.1).

Summary

Predicted to enable RNA binding activity and protein homodimerization activity. Predicted to be involved in gene silencing by RNA and piRNA metabolic process. Predicted to be located in P granule. Predicted to be part of PET complex. [provided by Alliance of Genome Resources, Apr 2022]

EXD1 Products(3)

mRNA	Protein	Name
NM_001286441.2	NP_001273370.1	piRNA biogenesis protein EXD1 isoform 1
NM_001385036.1	NP_001371965.1	piRNA biogenesis protein EXD1 isoform 3
NM_152596.4	NP_689809.2	piRNA biogenesis protein EXD1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXD1 Protein Structure

DNA_pol_A_exo1

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

piRNA biogenesis protein EXD1

exonuclease 3'-5' domain-containing protein 1

EXD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EXD1	Q8NHP7	EML2	Homo sapiens	O95834	Y2H Array	25416956
Intra	EXD1	Q8NHP7	EML2	Homo sapiens	O95834	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cerebral Creatine Deficiency Syndrome 3

Arginine:Glycine Amidinotransferase Deficiency	Agat Deficiency
Gatm Deficiency	Creatine Deficiency Syndrome Due To Agat Deficiency
L-Arginine:Glycine Amidinotransferase Deficiency	CCDS3
L-Arginine:Glycine Aminidotransferase Deficiency	Deficiency, Cerebral Creatine, Syndrome, Type 3

Cerebral Creatine Deficiency Syndrome

Deficiency, Cerebral Creatine, Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04582	EXD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EXD1	VGNC	VGNC:61995
Macaca mulatta	EXD1	VGNC	VGNC:72390
Bos taurus	EXD1	VGNC	VGNC:28639
Canis familiaris	EXD1	VGNC	VGNC:40508
Rattus norvegicus	EXD1	RGD	RGD:1561009
Mus musculus	EXD1	MGD	MGI:3045306

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