Il7r - interleukin 7 receptor Gene

Mus musculus

Also known as CD127; IL-7Ralpha

Gene ID: 16197 | Gene type: protein coding

About Il7r

Summary

Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]

Il7r Products(2)

mRNA	Protein	Name
NM_001355680.1	NP_001342609.1	interleukin-7 receptor subunit alpha isoform 2 precursor
NM_008372.4	NP_032398.3	interleukin-7 receptor subunit alpha isoform 1 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell homeostasis	IGI IGI: Inferred from genetic interaction	15909309	MGI
acts upstream of or within B cell proliferation	IGI IGI: Inferred from genetic interaction	15909309	MGI
acts upstream of or within B cell proliferation	IMP IMP: Inferred from mutant phenotype	15909309	MGI
acts upstream of or within T cell differentiation	IGI IGI: Inferred from genetic interaction	9215624	MGI
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	9215624	MGI
acts upstream of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	9215626	MGI
acts upstream of or within T cell homeostasis	IMP IMP: Inferred from mutant phenotype	9215624	MGI
acts upstream of T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	9215624	MGI
acts upstream of or within cell morphogenesis	IGI IGI: Inferred from genetic interaction	15909309	MGI
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	20364087	MGI
acts upstream of gene expression	IMP IMP: Inferred from mutant phenotype	18958875	MGI
acts upstream of or within immunoglobulin production	IGI IGI: Inferred from genetic interaction	15909309	MGI
acts upstream of or within lymph node development	IMP IMP: Inferred from mutant phenotype	12732660	MGI
acts upstream of or within negative regulation of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	9215624	MGI
acts upstream of or within negative regulation of T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	9215624	MGI
acts upstream of or within positive regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	9215626	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18958875	MGI
acts upstream of or within regulation of cell size	IDA IDA: Inferred from direct assay	15909309	MGI
acts upstream of or within regulation of cell size	IGI IGI: Inferred from genetic interaction	15909309	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12714519	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-7 receptor subunit alpha

IL-7 receptor alpha chain	IL-7 receptor subunit alpha
IL-7R subunit alpha	IL-7R-alpha
IL-7RA	interleukin 7 receptor alpha chain

Recombinant Il7r Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72536	CD127/IL-7RA Protein, Mouse (HEK293, Fc)	P16872 (E21-D239)	≥95%
HY-P76436	CD127/IL-7RA Protein, Mouse (HEK293, His)	P16872 (E21-D239)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99412	Lusvertikimab	Antagonist	99.41%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06780	IL7R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990911	Crebankitug	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il7r	NCBI	NCBI:3575
Macaca fascicularis	Il7r	NCBI	NCBI:102143679
Rattus norvegicus	Il7r	NCBI	NCBI:294797

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