TRPV3 - transient receptor potential cation channel subfamily V member 3 Gene

Homo sapiens

Also known as OLMS; VRL3; OLMS1; FNEPPK2

Gene ID: 162514 | Gene type: protein coding

About TRPV3

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:3,510,502-3,557,812 (from NCBI)

This gene has 11 transcripts (splice variants), 140 orthologues, 5 paralogues and is associated with 5 phenotypes. Biased expression in skin (RPKM 5.2), small intestine (RPKM 3.6) and 11 other tissues.

Summary

This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each Other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

TRPV3 Products(2)

mRNA	Protein	Name
NM_001258205.2	NP_001245134.1	transient receptor potential cation channel subfamily V member 3 isoform 1
NM_145068.4	NP_659505.1	transient receptor potential cation channel subfamily V member 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	12077604	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32572252	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26818531	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of hair cycle	IMP IMP: Inferred from mutant phenotype	21593771	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26818531	GOA
located in lysosome	IDA IDA: Inferred from direct assay	26818531	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26818531	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPV3 Protein Structure

Ank_2

Ank

Ion_trans

0
200
400
600
790 a.a.

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily V member 3

VRL-3

Related Diseases

Diseases

Alias

Olmsted Syndrome 1

OLMS1	Autosomal Dominant Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques 1	Ppkm1
Autosomal Dominant Olmsted Syndrome	Olmsted Syndrome
OLMS	Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Palmoplantar Keratoderma, Nonepidermolytic, Focal 2

FNEPPK2	Focal Nonepidermolytic Palmoplantar Keratoderma 2
Palmoplantar Keratoderma, Non-Epidermolytic, Focal 2	Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 2

Palmoplantar Keratoderma, Nonepidermolytic, Focal 1

Focal Nonepidermolytic Palmoplantar Keratoderma	Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma
FNEPPK1	Ppkfne
Keratoderma, Focal Nonepidermolytic Palmoplantar	Palmoplantar Keratoderma, Nonepidermolytic, Focal
Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas	Fneppk
Focal Nonepidermolytic Palmoplantar Keratoderma 1	Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1
Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Focal Palmoplantar Keratoderma

Focal Ppk	Focal Keratosis Palmoplantaris
Focal Palmoplantar Hyperkeratosis

Olmsted Syndrome, X-Linked

OLMSX	Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-Linked
Ppkmx	X-Linked Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
X-Linked Olmsted Syndrome	Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques, X-Linked

Erythromelalgia

Primary Erythromelalgia	Erythermalgia
Primary Erythermalgia	Mitchell Disease
Familial Erythromelalgia

Scapuloperoneal Spinal Muscular Atrophy

SPSMA	Amyotrophy, Neurogenic Scapuloperoneal, New England Type
Neurogenic Scapuloperoneal Amyotrophy, New England Type	Scapuloperoneal Neuronopathy
Spinal Muscular Atrophy, Scapuloperoneal	Amyotrophy Neurogenic Scapuloperoneal New England Type
Muscular Atrophy, Spinal	Scapuloperoneal Form Of Spinal Muscular Atrophy

Familial Episodic Pain Syndrome

Feps

Diabetic Neuropathy

Diabetic Neuropathies

Brachyolmia

Brachyrachia

Alopecia

Dentin Sensitivity

Sensitive Dentin

Metatropic Dysplasia

Metatropic Dwarfism	MTD
Metatropic Dysplasia Type 1	Metatropic Dysplasia, Nonlethal Dominant

Developmental And Epileptic Encephalopathy 24

DEE24	Epileptic Encephalopathy, Early Infantile, 24
Eiee24	Developmental And Epileptic Encephalopathy, 24
Early Infantile Epileptic Encephalopathy 24	Encephalopathy, Epileptic, Early Infantile, Type 24

Photoparoxysmal Response 1

Photosensitivity Disease	Photodermatitis
Photosensitivity Disorders	PPR1
Ppr	Photosensitivity
Photoconvulsive Reaction	Epilepsy, Photogenic
Photosensitivity Of Skin	Dermatitis, Phototoxic

Pachyonychia Congenita 1

Pachyonychia Congenita	Jadassohn-Lewandowsky Syndrome
Pachyonychia Congenita Syndrome	PC1
Pachyonychia Congenita, Jadassohn-Lewandowsky Type	Congenital Pachyonychia
Pachyonychia Congenita, Type 1	Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly
Jadassohn-Lewandowsky Syndrome, Formerly	Jackson-Lawler Type Pachyonychia Congenita
Pachyonychia Congenita Type 1	Jackson-Lawler Syndrome
Jadassohn-Lewandowski Syndrome	Pc
Pachyonychia Congenita Jackson-Lawler Type	Pachyonychia Congenita Jadassohn-Lewandowsky Type
Pachyonychia Congenita Jackson Lawler Type	Pc-1
Pachyonychia Congenita, Jadassohn Lewandowsky Type	Pachyonychia Congenita, Type 2

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0808	Camphor		≥98.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N8264	Moringin	Agonist	99.95%	Unkown
HY-157131	TRPV2-selective blocker 1	Inhibitor	99.84%	Unkown
HY-131868	TRPV3 antagonist 74a	Antagonist	99.85%	Unkown
HY-160900	RN-1665	Antagonist	99.93%	Unkown
HY-125527A	17(R)-Resolvin D1	Inhibitor	99.1%	Unkown
HY-RS15123	TRPV3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-118535	N-Oleoyl valine	Antagonist	/	Unkown
HY-N2941	Bisandrographolide C	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRPV3	MGD	MGI:2181407
Bos taurus	TRPV3	VGNC	VGNC:36399
Felis catus	TRPV3	VGNC	VGNC:66597
Rattus norvegicus	TRPV3	RGD	RGD:1564531
Canis familiaris	TRPV3	VGNC	VGNC:47884
Macaca mulatta	TRPV3	VGNC	VGNC:99308

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