DEDD2 - death effector domain containing 2 Gene

Homo sapiens

Also known as FLAME3; FLAME-3

Gene ID: 162989 | Gene type: protein coding

About DEDD2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,198,598-42,220,134 (from NCBI)

This gene has 13 transcripts (splice variants), 188 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 24.8), spleen (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

DEDD2 Products(3)

mRNA	Protein	Name
NM_001270614.2	NP_001257543.1	DNA-binding death effector domain-containing protein 2 isoform 1
NM_001270615.2	NP_001257544.1	DNA-binding death effector domain-containing protein 2 isoform 2
NM_133328.4	NP_579874.1	DNA-binding death effector domain-containing protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11741985	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic nuclear changes	IDA IDA: Inferred from direct assay	11741985	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	11741985	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	11741985	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	11741985	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DEDD2 Protein Structure

DED

0
100
200
300
326 a.a.

Protein Preferred Names

Protein Names

DNA-binding death effector domain-containing protein 2

DED-containing protein FLAME-3

Related Diseases

Diseases

Alias

Leukorrhea

Discharge - Leukorrhea

Leukorrhea Of Vagina

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03670	DEDD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DEDD2	MGD	MGI:1914629
Bos taurus	DEDD2	VGNC	VGNC:27985
Felis catus	DEDD2	VGNC	VGNC:61424
Macaca mulatta	DEDD2	VGNC	VGNC:109614
Canis familiaris	DEDD2	VGNC	VGNC:39873
Rattus norvegicus	DEDD2	RGD	RGD:1588968

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