APCDD1L - APC down-regulated 1 like Gene

Homo sapiens

Gene ID: 164284 | Gene type: protein coding

About APCDD1L

This gene has 3 transcripts (splice variants), 174 orthologues and 1 paralogue. Biased expression in salivary gland (RPKM 5.3), kidney (RPKM 1.7) and 6 other tissues.

Summary

Predicted to enable Wnt-protein binding activity. Predicted to be involved in negative regulation of Wnt signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

APCDD1L Products(2)

mRNA	Protein	Name
NM_001304787.2	NP_001291716.1	protein APCDD1-like isoform 2
NM_153360.3	NP_699191.1	protein APCDD1-like isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APCDD1L Protein Structure

APCDDC

0
100
200
300
400
501 a.a.

Protein Preferred Names

Protein Names

protein APCDD1-like

adenomatosis polyposis coli down-regulated 1 like

APCDD1L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	APCDD1L	Q8NCL9	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	APCDD1L	Q8NCL9	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	APCDD1L	Q8NCL9	YIPF1	Homo sapiens	Q9Y548	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 103

DFNB103	Autosomal Recessive Nonsyndromic Deafness 103
Autosomal Recessive Deafness 103	Deafness, Autosomal Recessive, 103
Deafness, Autosomal Recessive, Type 103

Amelogenesis Imperfecta, Type Ie

Aih1	Amelogenesis Imperfecta Type 1e
AI1E	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1
Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth	Enamel Hypoplasia, X-Linked
Amelogenesis Imperfecta Type Ie	Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1
Enamel Hypoplasia X-Linked	Amelogenesis Imperfecta, X-Linked 1
Amelogenesis Imperfecta, Type 1e	Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth
X-Linked Amelogenesis Imperfecta 1	X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1
X-Linked Enamel Hypoplasia	Amelogenesis Imperfecta X-Linked 1
Amelogenesis Imperfecta 1e	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e
Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth	Xai
X-Linked Amelogenesis Imperfecta	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00812	APCDD1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	APCDD1L	VGNC	VGNC:37981
Rattus norvegicus	APCDD1L	RGD	RGD:1562045
Macaca mulatta	APCDD1L	VGNC	VGNC:84543
Bos taurus	APCDD1L	VGNC	VGNC:26008
Felis catus	APCDD1L	VGNC	VGNC:59847

Name
Email *

	Sorry, but the email address you supplied was invalid.