2. Gene
  3. LRRN4 - leucine rich repeat neuronal 4 Gene

LRRN4 - leucine rich repeat neuronal 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NLRR4; NLRR-4; C20orf75; dJ1056H1.1

Gene ID: 164312 | Gene type: protein coding

About LRRN4

Cytogenetic location: 20p12.3 Genomic coordinates (GRCh38): 20:6,040,546-6,054,060 (from NCBI)

This gene has 4 transcripts (splice variants), 122 orthologues and 3 paralogues. Biased expression in lung (RPKM 6.4) and kidney (RPKM 1.0).

Summary

Predicted to be involved in long-term memory. Predicted to act upstream of or within visual learning. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

LRRN4 Products(1)

mRNA Protein Name
NM_152611.5 NP_689824.2 leucine-rich repeat neuronal protein 4 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRN4 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (123 - 181)

LRR_8

LRR_8: Leucine rich repeat (206 - 262)

fn3

fn3: Fibronectin type III domain (582 - 662)

  • 0
  • 200
  • 400
  • 600
  • 740 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat neuronal protein 4

neuronal leucine-rich repeat protein 4

LRRN4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LRRN4 Q8WUT4 DZIP1L Homo sapiens Q8IYY4
Y2H Array
32296183
Intra
LRRN4 Q8WUT4 DZIP1L Homo sapiens Q8IYY4
Y2H Prey Pooling
32296183
Intra
LRRN4 Q8WUT4 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
LRRN4 Q8WUT4 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
LRRN4 Q8WUT4 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
LRRN4 Q8WUT4 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
LRRN4 Q8WUT4 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra
LRRN4 Q8WUT4 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
LRRN4 Q8WUT4 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
LRRN4 Q8WUT4 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
LRRN4 Q8WUT4 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07839 LRRN4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07840 LRRN4CL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LRRN4 VGNC VGNC:31041
Rattus norvegicus LRRN4 RGD RGD:1305256
Mus musculus LRRN4 MGD MGI:2445154
Canis familiaris LRRN4 VGNC VGNC:42827
Macaca mulatta LRRN4 VGNC VGNC:107797
Felis catus LRRN4 VGNC VGNC:63313