APOBEC3H - apolipoprotein B mRNA editing enzyme catalytic subunit 3H Gene

Homo sapiens

Also known as A3H; ARP10; ARP-10

Gene ID: 164668 | Gene type: protein coding

About APOBEC3H

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,097,244-39,104,067 (from NCBI)

This gene has 7 transcripts (splice variants), 88 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 1.2), colon (RPKM 1.0) and 22 other tissues.

Summary

This gene encodes a member of the apolipoprotein B mRNA-editing Enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 Infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

APOBEC3H Products(4)

mRNA	Protein	Name
NM_001166002.3	NP_001159474.2	DNA dC->dU-editing enzyme APOBEC-3H isoform SV-182
NM_001166003.3	NP_001159475.2	DNA dC->dU-editing enzyme APOBEC-3H isoform SV-200
NM_001166004.3	NP_001159476.2	DNA dC->dU-editing enzyme APOBEC-3H isoform SV-154
NM_181773.5	NP_861438.3	DNA dC->dU-editing enzyme APOBEC-3H isoform SV-183

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytidine deaminase activity	IDA IDA: Inferred from direct assay	16571802	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22915799	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA cytosine deamination	IDA IDA: Inferred from direct assay	16571802	GOA
involved in clearance of foreign intracellular DNA	IDA IDA: Inferred from direct assay	20062055	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21835787	GOA
involved in negative regulation by host of viral genome replication	IMP IMP: Inferred from mutant phenotype	18827027	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA IDA: Inferred from direct assay	18779051	GOA
involved in retrotransposon silencing	IDA IDA: Inferred from direct assay	18779051	GOA
involved in retrotransposon silencing	IMP IMP: Inferred from mutant phenotype	18827027	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	22915799	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	29290613	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18779051	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18779051	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC3H Protein Structure

APOBEC_N

0
100
200 a.a.

Protein Preferred Names

Protein Names

DNA dC->dU-editing enzyme APOBEC-3H

APOBEC-related protein 10

Related Diseases

Diseases

Alias

Plantar Wart

Verruca Plantaris	Verrucae On Sole Of Foot
Mosaic Plantar Warts

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Bone Giant Cell Sarcoma

Giant Cell Sarcoma Of The Bone

Giant Cell Tumor Of Bone, Malignant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00841	APOBEC3H Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	APOBEC3H	VGNC	VGNC:108124
Macaca mulatta	APOBEC3H	VGNC	VGNC:69894
Rattus norvegicus	APOBEC3H	RGD	RGD:1307800

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