Junb - jun B proto-oncogene Gene

Mus musculus

Gene ID: 16477 | Gene type: protein coding

About Junb

Chromosome 8: 85,701,113-85,705,347 reverse strand.GRCm39:CM001001.3

This gene has 2 transcripts (splice variants), 236 orthologues, 2 paralogues and is associated with 20 phenotypes.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including decidualization; embryo development; and osteoblast proliferation. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor AP-1 complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and hemolymphoid system gland. Used to study systemic lupus erythematosus. Orthologous to human JUNB (JunB proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Junb Products(1)

mRNA	Protein	Name
NM_008416.3	NP_032442.1	transcription factor JunB

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12220541	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	11818961	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	11818961	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19289495	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14610205	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell differentiation	IDA IDA: Inferred from direct assay	11456449	MGI
acts upstream of or within cellular response to calcium ion	IDA IDA: Inferred from direct assay	19303854	MGI
acts upstream of or within decidualization	IMP IMP: Inferred from mutant phenotype	10022836	MGI
acts upstream of or within embryonic process involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	10022836	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	10022836	MGI
acts upstream of or within labyrinthine layer blood vessel development	IMP IMP: Inferred from mutant phenotype	10022836	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	14769860	MGI
acts upstream of or within osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	14769860	MGI
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	14769860	MGI
acts upstream of or within osteoclast proliferation	IMP IMP: Inferred from mutant phenotype	14769860	MGI
acts upstream of or within positive regulation of cell differentiation	IDA IDA: Inferred from direct assay	11456449	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11818961	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11818961	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	11818961	MGI
acts upstream of or within trophectodermal cell differentiation	IDA IDA: Inferred from direct assay	11456449	MGI
acts upstream of or within trophectodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	10022836	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	10022836	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Junb Protein Structure

Jun

bZIP_Jun

0
100
200
300
344 a.a.

Protein Preferred Names

Protein Names

transcription factor JunB

Jun-B oncogene	myD21
transcription factor AP-1 subunit JunB	transcription factor jun-B

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07057	JUNB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07058	Junb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07059	Junb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Junb	NCBI	NCBI:3726

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