DNAJB8 - DnaJ heat shock protein family (Hsp40) member B8 Gene

Homo sapiens

Also known as DJ6; CT156

Gene ID: 165721 | Gene type: protein coding

About DNAJB8

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:128,462,437-128,466,890 (from NCBI)

This gene has 2 transcripts (splice variants), 412 orthologues and 11 paralogues. Restricted expression toward testis (RPKM 16.6).

Summary

The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a Cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]

DNAJB8 Products(1)

mRNA	Protein	Name
NM_153330.6	NP_699161.1	dnaJ homolog subfamily B member 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein folding chaperone	IDA IDA: Inferred from direct assay	23612975	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	21231916	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	21231916	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	23612975	GOA
involved in negative regulation of inclusion body assembly	IDA IDA: Inferred from direct assay	21231916	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21231916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJB8 Protein Structure

DnaJ

0
100
200
232 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily B member 8

DnaJ (Hsp40) homolog, subfamily B, member 8

Related Diseases

Diseases

Alias

Fatal Infantile Hypertonic Myofibrillar Myopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03870	DNAJB8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DNAJB8	RGD	RGD:1561981
Canis familiaris	DNAJB8	VGNC	VGNC:54595
Felis catus	DNAJB8	VGNC	VGNC:78442
Mus musculus	DNAJB8	MGD	MGI:1922801

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