2. Gene
  3. MIER3 - MIER family member 3 Gene

MIER3 - MIER family member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 166968 | Gene type: protein coding

About MIER3

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:56,919,603-56,952,209 (from NCBI)

This gene has 11 transcripts (splice variants), 236 orthologues and 5 paralogues. Ubiquitous expression in colon (RPKM 18.3), duodenum (RPKM 12.6) and 25 other tissues.

Summary

Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

MIER3 Products(3)

mRNA Protein Name
NM_001297598.2 NP_001284527.1 mesoderm induction early response protein 3 isoform 1
NM_001297599.2 NP_001284528.1 mesoderm induction early response protein 3 isoform 2
NM_152622.5 NP_689835.3 mesoderm induction early response protein 3 isoform 3
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
NOT contributes to histone deacetylase activity IDA
IDA: Inferred from direct assay
28046085 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
28046085 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
28046085 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIER3 Protein Structure

ELM2

ELM2: ELM2 domain (176 - 224)

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  • 550 a.a.
Protein Preferred Names Protein Names

mesoderm induction early response protein 3

mesoderm induction early response 1, family member 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08444 MIER3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MIER3 VGNC VGNC:43231
Rattus norvegicus MIER3 RGD RGD:1311241
Bos taurus MIER3 VGNC VGNC:31471
Macaca mulatta MIER3 VGNC VGNC:74836
Mus musculus MIER3 MGD MGI:2442317
Felis catus MIER3 VGNC VGNC:63502