L1cam - L1 cell adhesion molecule Gene

Mus musculus

Also known as L1; CD171; NCAM-L1; N-CAM-L1

Gene ID: 16728 | Gene type: protein coding

About L1cam

Summary

Enables several functions, including identical protein binding activity; Integrin binding activity; and sialic acid binding activity. Acts upstream of or within several processes, including cell-cell adhesion mediated by integrin; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in external side of plasma membrane; presynaptic membrane; and terminal bouton. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]

L1cam Products(2)

mRNA	Protein	Name
NM_001374694.1	NP_001361623.1	neural cell adhesion molecule L1 isoform 2 precursor
NM_008478.3	NP_032504.3	neural cell adhesion molecule L1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	8557754	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	18550718	MGI
enables integrin binding	IDA IDA: Inferred from direct assay	8557754	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7613634	MGI
enables sialic acid binding	IDA IDA: Inferred from direct assay	11283023	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	18650339	MGI
acts upstream of or within axon guidance	IGI IGI: Inferred from genetic interaction	18550718	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	12533613	MGI
acts upstream of calcium-mediated signaling	IDA IDA: Inferred from direct assay	7613634	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	7613634	MGI
acts upstream of or within cell-cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	8557754	MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: Inferred from mutant phenotype	8557754	MGI
acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules	IMP IMP: Inferred from mutant phenotype	7669058	MGI
acts upstream of or within homotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	7613634	MGI
acts upstream of or within leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	8117278	MGI
involved in maintenance of synapse structure	IDA IDA: Inferred from direct assay	30846310	MGI
involved in maintenance of synapse structure	IMP IMP: Inferred from mutant phenotype	30846310	MGI
acts upstream of or within neuron projection development	IDA IDA: Inferred from direct assay	11283023	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	11283023	MGI
acts upstream of or within positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	7613634	MGI
acts upstream of or within positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	7669058	MGI
involved in regulation of synapse assembly	IDA IDA: Inferred from direct assay	30846310	MGI
involved in regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	30846310	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	30846310	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	30846310	MGI
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	16537644	MGI
located in cell surface	IDA IDA: Inferred from direct assay	12514225	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7613634	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16537644	MGI
located in membrane	IDA IDA: Inferred from direct assay	11283023	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	34380733	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	16537644	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	16537644	MGI
located in terminal bouton	IDA IDA: Inferred from direct assay	16537644	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neural cell adhesion molecule L1

Recombinant L1cam Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77732	L1CAM Protein, Mouse (HEK293, His)	P11627 (I20-E1123)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07481	L1CAM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	L1cam	NCBI	NCBI:3897

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