THAP5 - THAP domain containing 5 Gene

Homo sapiens

Gene ID: 168451 | Gene type: protein coding

About THAP5

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:108,541,759-108,569,768 (from NCBI)

This gene has 8 transcripts (splice variants) and 103 orthologues. Ubiquitous expression in thyroid (RPKM 13.7), testis (RPKM 10.7) and 25 other tissues.

Summary

Enables protease binding activity. Involved in negative regulation of cell cycle and negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

THAP5 Products(5)

mRNA	Protein	Name
NM_001130475.3	NP_001123947.1	THAP domain-containing protein 5 isoform 1
NM_001287598.1	NP_001274527.1	THAP domain-containing protein 5 isoform 3
NM_001287599.1	NP_001274528.1	THAP domain-containing protein 5 isoform 3
NM_001287601.1	NP_001274530.1	THAP domain-containing protein 5 isoform 3
NM_182529.3	NP_872335.2	THAP domain-containing protein 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IPI IPI: Inferred from physical interaction	19502560	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19502560	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21110952	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	21110952	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19502560	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THAP5 Protein Structure

THAP

0
100
200
300
395 a.a.

Protein Preferred Names

Protein Names

THAP domain-containing protein 5

Related Diseases

Diseases

Alias

Townes-Brocks Syndrome

Townes Syndrome	Renal-Ear-Anal-Radial Syndrome
Anus, Imperforate, With Hand, Foot And Ear Anomalies	Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome
Rear Syndrome	Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs
Tbs	Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs
Imperforate Anus With Hand, Foot And Ear Anomalies	Anal-Ear-Renal-Radial Malformation Syndrome
Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Imperforate Anus-Hand And Foot Anomalies Syndrome
Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs

Branchiootorenal Syndrome

Branchio-Oto-Renal Syndrome	Bor Syndrome
Branchiootorenal Dysplasia	Melnick-Fraser Syndrome
Branchiootorenal Spectrum Disorders	Branchio-Otorenal Dysplasia
Branchio Oto Renal Syndrome	Branchiootorenal/Branchiootic Syndrome
Bo Syndrome	Bor
Bos	Branchio-Otorenal Syndrome
Branchiootic Syndrome	Branchiootorenal Syndrome
Branchiootic Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14476	THAP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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