Lepr - leptin receptor Gene

Mus musculus

Also known as db; Obr; obl; Leprb; Modb1; LEPROT; OB-RGRP; diabetes; obese-like

Gene ID: 16847 | Gene type: protein coding

About Lepr

Summary

Enables Leptin receptor activity. Involved in several processes, including energy homeostasis; leptin-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including glial cell proliferation; glycogen metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb segment; and skeleton. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (Leptin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Lepr Products(3)

mRNA	Protein	Name
NM_001122899.2	NP_001116371.1	leptin receptor isoform 3 precursor
NM_010704.2	NP_034834.1	leptin receptor isoform 2 precursor
NM_146146.3	NP_666258.2	leptin receptor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables leptin receptor activity	IMP IMP: Inferred from mutant phenotype	12594516	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16698021	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell differentiation	IMP IMP: Inferred from mutant phenotype	9732873	MGI
involved in bone growth	IMP IMP: Inferred from mutant phenotype	10660043	MGI
acts upstream of or within cholesterol metabolic process	IGI IGI: Inferred from genetic interaction	15995171	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	12594516	MGI
acts upstream of or within glial cell proliferation	IGI IGI: Inferred from genetic interaction	28973665	MGI
acts upstream of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	24051374	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	12594516	MGI
acts upstream of or within glycogen metabolic process	IGI IGI: Inferred from genetic interaction	28973665	MGI
involved in leptin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12594516	MGI
acts upstream of or within negative regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	24051374	MGI
acts upstream of or within negative regulation of hydrolase activity	IGI IGI: Inferred from genetic interaction	15995171	MGI
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	9438411	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	11003997	MGI
involved in regulation of bone remodeling	IMP IMP: Inferred from mutant phenotype	10660043	MGI
involved in regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	12594516	MGI
involved in response to leptin	IMP IMP: Inferred from mutant phenotype	12594516	MGI
involved in sexual reproduction	IMP IMP: Inferred from mutant phenotype	12594516	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leptin receptor

B219	LEP-R
OB receptor	leptin receptor gene-related protein

Recombinant Lepr Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72523	Leptin R/LEPR Protein, Mouse (HEK293, His)	P48356-1 (L22-G839)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990631	Mibavademab	Inhibitor	98.66%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07594	LEPR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lepr	NCBI	NCBI:3953

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