Xcl1 - chemokine (C motif) ligand 1 Gene

Mus musculus

Also known as LTN; ATAC; Lptn; SCM-1; Scyc1; SCM-1a

Gene ID: 16963 | Gene type: protein coding

About Xcl1

Summary

Enables chemokine activity. Involved in several processes, including mature natural killer cell chemotaxis; positive regulation of leukocyte migration; and positive regulation of production of molecular mediator of immune response. Acts upstream of or within chemotaxis and release of sequestered calcium ion into cytosol. Located in extracellular space. Orthologous to several human genes including XCL1 (X-C motif chemokine ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Xcl1 Products(1)

mRNA	Protein	Name
NM_008510.3	NP_032536.1	lymphotactin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	7973732	MGI
enables chemokine receptor binding	IDA IDA: Inferred from direct assay	9632725	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to interleukin-4	IDA IDA: Inferred from direct assay	9013979	MGI
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	9013979	MGI
acts upstream of or within chemotaxis	IDA IDA: Inferred from direct assay	10518929	MGI
acts upstream of or within establishment of localization in cell	IDA IDA: Inferred from direct assay	10518929	MGI
involved in mature natural killer cell chemotaxis	IDA IDA: Inferred from direct assay	9029087	MGI
involved in positive regulation of B cell chemotaxis	IDA IDA: Inferred from direct assay	11181058	MGI
involved in positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	9973465	MGI
involved in positive regulation of T cell chemotaxis	IDA IDA: Inferred from direct assay	8757601	MGI
involved in positive regulation of T cell cytokine production	IDA IDA: Inferred from direct assay	9029087	MGI
involved in positive regulation of T-helper 1 cell cytokine production	IDA IDA: Inferred from direct assay	9973465	MGI
involved in positive regulation of T-helper 2 cell cytokine production	IDA IDA: Inferred from direct assay	9973465	MGI
involved in positive regulation of immunoglobulin production in mucosal tissue	IDA IDA: Inferred from direct assay	9973465	MGI
involved in positive regulation of leukocyte chemotaxis	IDA IDA: Inferred from direct assay	7973732	MGI
involved in positive regulation of natural killer cell chemotaxis	IDA IDA: Inferred from direct assay	9029087	MGI
involved in positive regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	11181058	MGI
involved in positive regulation of thymocyte migration	IDA IDA: Inferred from direct assay	7973732	MGI
acts upstream of or within release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	10518929	MGI
involved in release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	7973732	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	9973465	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lymphotactin

c motif chemokine 1	chemokine XCL1
cytokine SCM-1	lymphotaxin
small inducible cytokine subfamily C, member 1 (lymphotactin)	small-inducible cytokine C1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15866	XCL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xcl1	NCBI	NCBI:6375
Canis familiaris	Xcl1	NCBI
Macaca fascicularis	Xcl1	NCBI	NCBI:102131550
Susscrofa domestica	Xcl1	NCBI
Rattus norvegicus	Xcl1	NCBI	NCBI:171371
Macaca mulatta	Xcl1	NCBI	NCBI:574367

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