QSOX2 - quiescin sulfhydryl oxidase 2 Gene

Homo sapiens

Also known as SOXN; QSCN6L1

Gene ID: 169714 | Gene type: protein coding

About QSOX2

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,206,333-136,245,812 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 8.6), spleen (RPKM 7.1) and 25 other tissues.

Summary

QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]).[supplied by OMIM, Jun 2009]

QSOX2 Products(1)

mRNA	Protein	Name
NM_181701.4	NP_859052.3	sulfhydryl oxidase 2 precursor

QSOX2 Protein Structure

Thioredoxin

Evr1_Alr

0
200
400
600
698 a.a.

Protein Preferred Names

Protein Names

sulfhydryl oxidase 2

neuroblastoma-derived sulfhydryl oxidase

Related Diseases

Diseases

Alias

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Deafness, Autosomal Recessive 33

DFNB33	Autosomal Recessive Nonsyndromic Deafness 33
Autosomal Recessive Deafness 33

Deafness, Autosomal Dominant 50

DFNA50	Autosomal Dominant Nonsyndromic Deafness 50
Autosomal Dominant Deafness 50	Deafness, Autosomal Dominant, Type 50

Deafness, Autosomal Recessive 79

DFNB79	Autosomal Recessive Nonsyndromic Deafness 79
Autosomal Recessive Deafness 79	Deafness, Autosomal Recessive, 79
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 79	Deafness, Autosomal Recessive, Type 79

Pituitary Adenoma 5, Multiple Types

PITA5	Pituitary Adenoma 5
{Pituitary Adenoma 5, Multiple Types}

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11510	QSOX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	QSOX2	RGD	RGD:1584720
Felis catus	QSOX2	VGNC	VGNC:64462
Mus musculus	QSOX2	MGD	MGI:2387194
Macaca mulatta	QSOX2	VGNC	VGNC:76568
Canis familiaris	QSOX2	VGNC	VGNC:45239
Bos taurus	QSOX2	VGNC	VGNC:33606

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