2. Gene
  3. Alad - aminolevulinate, delta-, dehydratase Gene

Alad - aminolevulinate, delta-, dehydratase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Lv; ALADH

Gene ID: 17025 | Gene type: protein coding

About Alad

Summary

Enables identical protein binding activity and porphobilinogen synthase activity. Acts upstream of or within cellular response to interleukin-4 and heme biosynthetic process. Predicted to be located in extracellular space. Predicted to be active in cytosol. Is expressed in several structures, including liver; lung; metanephros; spleen; and yolk sac. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Apr 2022]

Alad Products(2)

mRNA Protein Name
NM_001276446.1 NP_001263375.1 delta-aminolevulinic acid dehydratase
NM_008525.4 NP_032551.3 delta-aminolevulinic acid dehydratase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables porphobilinogen synthase activity IDA
IDA: Inferred from direct assay
4959158 MGI
enables porphobilinogen synthase activity IMP
IMP: Inferred from mutant phenotype
5393940 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to interleukin-4 IDA
IDA: Inferred from direct assay
9798653 MGI
involved in heme A biosynthetic process IDA
IDA: Inferred from direct assay
14050799 MGI
involved in heme A biosynthetic process IMP
IMP: Inferred from mutant phenotype
5393940 MGI
involved in heme B biosynthetic process IDA
IDA: Inferred from direct assay
14050799 MGI
involved in heme B biosynthetic process IMP
IMP: Inferred from mutant phenotype
5393940 MGI
involved in heme O biosynthetic process IDA
IDA: Inferred from direct assay
14050799 MGI
involved in heme O biosynthetic process IMP
IMP: Inferred from mutant phenotype
5393940 MGI
acts upstream of or within heme biosynthetic process IDA
IDA: Inferred from direct assay
4959158 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cytosol IDA
IDA: Inferred from direct assay
4981581 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta-aminolevulinic acid dehydratase

porphobilinogen synthase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00553 ALAD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alad NCBI NCBI:210
Macaca fascicularis Alad NCBI NCBI:102130527