CLEC4C - C-type lectin domain family 4 member C Gene

Homo sapiens

Also known as DLEC; HECL; BDCA2; CD303; BDCA-2; CLECSF7; CLECSF11; PRO34150

Gene ID: 170482 | Gene type: protein coding

About CLEC4C

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:7,729,383-7,749,541 (from NCBI)

This gene has 6 transcripts (splice variants), 747 orthologues and 14 paralogues. Biased expression in lymph node (RPKM 1.5), spleen (RPKM 0.9) and 6 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

CLEC4C Products(4)

mRNA	Protein	Name
NM_001371390.1	NP_001358319.1	C-type lectin domain family 4 member C isoform 1
NM_001371391.1	NP_001358320.1	C-type lectin domain family 4 member C isoform 3
NM_130441.3	NP_569708.1	C-type lectin domain family 4 member C isoform 1
NM_203503.2	NP_987099.1	C-type lectin domain family 4 member C isoform 2

CLEC4C Protein Structure

Lectin_C

0
100
200
213 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 4 member C

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11

Recombinant CLEC4C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71679	CLEC4C Protein, Human (HEK293, His, Myc)	Q8WTT0-1 (N45-I213)	≥95%
HY-P72014	CLEC4C Protein, Human (His-SUMO)	Q8WTT0-1 (N45-I213)	≥95%
HY-P78387	CLEC4C Protein, Human (Biotinylated, HEK293, His-Avi)	Q8WTT0-1 (F46-I213)	≥95%

Related Diseases

Diseases

Alias

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction

Left Ventricular Noncompaction 3	Dilated Cardiomyopathy 1c
CMD1C	Cardiomyopathy, Hypertrophic, 24
Dilated Cardiomyopathy With Left Ventricular Noncompaction	Cardiomyopathy, Dilated, 1c, With Or Without Lvnc
Cmdc1	Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction
Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction	Cardiomyopathy Dilated With Left Ventricular Noncompaction
Cardiomyopathy, Familial Hypertrophic 24	CMH24
Left Ventricular Non-Compaction 3	LVNC3
Cardiomyopathy, Dilated 1c	Familial Hypertrophic Cardiomyopathy 24
Cardiomyopathy, Dilated, 1c

Inflammatory Bowel Disease 23

IBD23

Pitt-Hopkins Syndrome

PTHS	Encephalopathy, Severe Epileptic, With Autonomic Dysfunction
Mental Retardation, Syndromal, With Intermittent Hyperventilation	Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea
Pitt Hopkins Syndrome	Phs
Encephalopathy Severe Epileptic With Autonomic Dysfunction

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02792	CLEC4C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CLEC4C	MGD	MGI:1917060
Rattus norvegicus	CLEC4C	RGD	RGD:1359354
Macaca mulatta	CLEC4C	VGNC	VGNC:99915
Macaca fascicularis	CLEC4C	NCBI	NCBI:102147129
Others	CLEC4C	NCBI

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