S100Z - S100 calcium binding protein Z Gene

Homo sapiens

Also known as Gm625; S100-zeta

Gene ID: 170591 | Gene type: protein coding

About S100Z

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,850,014-76,952,953 (from NCBI)

This gene has 3 transcripts (splice variants), 184 orthologues and 21 paralogues. Low expression observed in reference dataset.

Summary

Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression patterns. For additional background information on S100 proteins, see MIM 114085.[supplied by OMIM, Mar 2008]

S100Z Products(1)

mRNA	Protein	Name
NM_130772.4	NP_570128.2	protein S100-Z

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	11747429	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11747429	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11747429	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100Z Protein Structure

S_100

0
99 a.a.

Protein Preferred Names

Protein Names

protein S100-Z

S100 calcium binding protein, zeta

S100Z Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	S100Z	Q8WXG8	S100B	Homo sapiens	P04271	Y2H Array	32296183
Intra	S100Z	Q8WXG8	S100B	Homo sapiens	P04271	Y2H Prey Pooling	32296183
Intra	S100Z	Q8WXG8	RBM48	Homo sapiens	Q5RL73	Y2H Array	32296183
Intra	S100Z	Q8WXG8	RBM48	Homo sapiens	Q5RL73	Y2H Prey Pooling	32296183
Intra	S100Z	Q8WXG8	S100A10	Homo sapiens	P60903	Y2H Prey Pooling	32296183
Intra	S100Z	Q8WXG8	S100A10	Homo sapiens	P60903	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pulmonary Systemic Sclerosis

Lung Disease With Systemic Sclerosis

Lung Involvement In Systemic Sclerosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12390	S100Z Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	S100Z	RGD	RGD:1562902
Mus musculus	S100Z	MGD	MGI:2685471
Felis catus	S100Z	VGNC	VGNC:102311
Bos taurus	S100Z	VGNC	VGNC:34251

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