2. Gene
  3. ADAMTS15 - ADAM metallopeptidase with thrombospondin type 1 motif 15 Gene

ADAMTS15 - ADAM metallopeptidase with thrombospondin type 1 motif 15 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 170689 | Gene type: protein coding

About ADAMTS15

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:130,448,645-130,476,645 (from NCBI)

This gene has 1 transcript (splice variant), 269 orthologues and 25 paralogues. Biased expression in fat (RPKM 10.9), placenta (RPKM 8.5) and 13 other tissues.

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature Enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]

ADAMTS15 Products(1)

mRNA Protein Name
NM_139055.4 NP_620686.1 A disintegrin and metalloproteinase with thrombospondin motifs 15 preproprotein

ADAMTS15 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (24 - 143)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (218 - 427)

TSP_1

TSP_1: Thrombospondin type 1 domain (521 - 570)

ADAM_spacer1

ADAM_spacer1: ADAM-TS Spacer 1 (683 - 801)

TSP_1

TSP_1: Thrombospondin type 1 domain (846 - 892)

TSP_1

TSP_1: Thrombospondin type 1 domain (900 - 950)

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  • 950 a.a.
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 15

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15, preproprotein

Related Diseases

Diseases Alias
Spondyloepimetaphyseal Dysplasia, Missouri Type

Metaphyseal Anadysplasia 1

Semd, Missouri Type

Spondyloepimetaphyseal Dysplasia Type 2

SEMDM

Spondyloepimetaphyseal Dysplasia Missouri Type

Missouri Type Of Spondyloepimetaphyseal Dysplasia

Semd Missouri Type

Semd Type 2

MANDP1

Semd-Mo

Spondyloepimetaphyseal Dysplasia Type Missouri

Spondylometaepiphyseal Dysplasia Type Missouri

Anadysplasia, Metaphyseal, Type 1
Winchester Syndrome

WNCHRS

Winchester Disease

Winchester-Grossman Syndrome
Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage

Familial Berry Aneurysm

Familial Intracranial Saccular Aneurysm

Saccular Cerebral Aneurysm

Aneurysm, Intracranial Berry

Aneurysmal Subarachnoid Hemorrhage

Aneurysm, Intracranial Berry, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00296 ADAMTS15 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADAMTS15 MGD MGI:2449569
Rattus norvegicus ADAMTS15 RGD RGD:1309770
Canis familiaris ADAMTS15 VGNC VGNC:53260
Felis catus ADAMTS15 VGNC VGNC:59589
Bos taurus ADAMTS15 VGNC VGNC:25619
Macaca mulatta ADAMTS15 VGNC VGNC:69424
Others ADAMTS15 NCBI